Abstract
Upto the end of year 2010, there have been 299 studies published in 114 medical journals (92 integrative, 9 homeopathy and 13 CAM journals) including 11 meta-analysis, 8 systematic reviews including 1 cochrane review (out of approximately 20 systematic reviews published) and 81 RCT (68 DBRPCT + 2 SBRPCT + 6 DBRCT + 1 RPCT + 4 RCT) out of approx 225 RCT published) in evidence of homoeopathy to produce significant to substantial health benefits in a wide array of health conditions.
URL Links to 279 studies (Journal-wise) including 171 FULL TEXT papers are available as compendium on this webpage in Section-A from B to F. Among those 171, 155 are available as PDF which can be viewed at or downloaded from Google Drive, and 57 are also available at Scribd
The compendium is prepared by mining 14 online electronic databases: PubMed Central (National Library of medicine, USA), MedWorm, British library Direct (type homeopathy in search box), Centre for Reviews and Dissemination (type homeopathy in search box), Scirus, Google Scholar,HomBRex,The Allied and Complementary Medicine Database,Cochrane Central Register of Controlled Trial,Embase,Science Citation Index,Lilacs and CAM QUESTand Clinical Outcome Research in Homeopathy (http://www.carstens-stiftung.de/core-hom/login.php)
Exclusion Criterion (Which studies are not included?)
1. Studies on Plants and Animals
2. Statistically non-significant studies (Probability value<0.05, odds ratio >1 indicates statistical significance)
3. Non-peer reviewed studies from year 1893 onwards
4. Studies published in non-journal paper
5. Studies in which combination of homeopathic medicine with any other medicine is prescribed
6. Studies in which medicine is perceived to be homeopathic but is not such as radionically prepared or different potencies of same medicine mixed together
CONTENTS: Section-A
B. Basic Fundamental Research [47 studies]
C. Super-Avogadro Dilution Research [18 studies]
D. Research Models (1983-2010) [22 studies]
E. Drug Development
E1. Homeopathic Pathogenetic Trials/Drug Provings (1988-2010) [9 studies]
E2. Drug Standardisation [3 studies]
F. Clinical Research
F1. Meta Analysis (1991-2010) [11 studies] and Systematic Reviews (2000-2010) [8 studies] of RCTs
F2. Triple-Blind Randomised Placebo Controlled Trial [1 study]
F3. Double-blind Randomised Placebo-Controlled Trial (1980-2010) [68 studies]
F4. Double-blind Randomised Controlled Trial (other-than-placebo [active non-homeopathic intervention)controlled] (1998-2009) [6 studies]
F5.Single-blind Randomised Placebo-Controlled Trial [2 study]
F6.Randomised Placebo- Controlled Trial (RPCT) [1 study]
F7. Randomised Controlled Trial (1983-2009) [4 studies]
F8. Double-blind Placebo-Controlled Trial (1996-2008) [4 studies]
F9. Double-Blind Studies (1943-2010) [3 studies]
F10. Primary Health Care Studies (Observational/Cohort/Pilot Studies) [97 studies]
F11. Review Articles (other thsn systematic reviews) (2005-2010) [12 studies]
G. Table: Distribution of Studies
I. Lives saved by Homeopathy in Epidemics and Pandemics
J1. Animal Studies (Veterinary Homeopathy)
J2. Plant Studies
K1. Significant Years of Research
K2. Books on research in Homeopathy
L1. Potency Selection
L2. Discussion Forums
Section-B
A. Genetic Research
B1. Identification of homeopathic medicines (to distinguish one homeopathic medicine from the other) [4 techniques]
B2. To distinguish homeopathic medicine from the solvent/control [5 techniques]
C. Applied Research in specific medical condition
D: Comparison with Con-Med and Placebo
D1. Homeopathy superior to ConMed [17 studies]
D2. Homeopathy cost-effective than ConMed [3 studies]
D3. Homeopathy equals Con-Med [10 studies]
D4. Homeopathy superior to placebo [88 studies]
E: Outcome Studies
E1. Homeopathy improving quality of life [7 studies]
E2. Safety Profile of Homeopathic Medicines
E3.Homeopathy cost-effective than ConMed [3 studies]
F. in-vitro evidence of homeopathy [28 studies]
G. Research Papers on Combination Remedies [52 studies]
SECTION-A
B. BASIC FUNDAMENTAL RESEARCH
1.Annals of the New York Academy of Sciences
Thermodynamics of extremely diluted aqueous solutions (1999) FULL TEXT // Successive dilutions and sucussions may alter permanently the physical-chemical properties of the solvent water
2.Journal of Thermal Analysis and Calorimetry
New Physico-Chemical Properties of Extremely-Diluted Aqueous Solutions (2004) FULL TEXT // The procedure of dilutions and succussions is capable of modifying in a permanent way the physico-chemical features of water.
3. Journal of Solution Chemistry
New Physico-Chemical Properties of Extremely Dilute Solutions. A Conductivity Study at 25 °C (2008) FULL TEXT // electrical conductivity increases as potency increases. Sucussion may form dissipative structures https://docs.google.com/file/d/0B0b69JqzK_44aWJqSFlmVnhQNHI4WlBseW50YkhRU3J3X3Iw/edit
4.IETE Journal of Research
Software for measuring physiological variability (2008) FULL TEXT
5. Perspective in Public Health
Is Homeopathy Possible? (2006) FULL TEXT
6. Materials Research Innovations
The structure of liquid water (2005) FULL TEXT
7. Human and Experimental Toxicology
Postconditioning hormesis and the homeopathic Similia principle: Molecular aspects (2010) //scientific evidence of ‘principle of similars’
8. Water Journal
Domains of Water Molecules Provide Mechanisms of Potentization (2010) FULL TEXT
9.Homeopathy
Double-blind Placebo-controlled homeopathic patho-genetic trials (2006) FULL TEXT
Proving and therapeutic experiments in the HomBRex basic homeopathy research database (2007)
nuclear magnetic resonance spectroscopy on Kalium bichromicum (2008) FULL TEXT // 3c differs from 4c
Placebo effect size in placebo-controlled clinical trials of individualised homeopathy are same as that of conventional trials (2010) FULL TEXT
Nux vomica and Calendula have significant effect on gene expression (2010) FULL TEXT
Solitons (2005) FULL TEXT //duration of memory is 10 minutes
Dissipative structures in extremely dilute aqueous solutions (2007) FULL TEXT
Can low-temperature thermoluminescence cast light on the nature of ultra-high dilutions? (2007) FULL TEXT //Low temperature thermo-luminesence involves freezing water to the temperature of liquid nitrogen, bombarding it with x- or γ rays, then warming it, whereupon it emits a characteristic glow.
Effect of dielectric dispersion on potentised homeopathic medicines (2010) //homeopathic medicines when subjected to variable frequency electric field shows dielectric dispersion
Complexity science and homeopathy: a synthetic overview (2003) FULL TEXT
The defining role of structure including epitaxy in the plausability of homeopathy (2007) FULL TEXT
Distinguishing Natrum Mur 30 from water by High voltage plasma (2008)// electrical impedance of Natrum Mur 30c differ from water
Delayed luminescence of high homeopathic potencies on sugar globuli (2008) FULL TEXT
Medicines beyond 12C retains nano-grams of fine nano-particles of original starting material (2010) FULL TEXT
Rhus Tox 6c, 30c, 200c, 1M stimulates phagocytosis, candidacidal activity and chemotaxis of poly-morpho-nuclear cells (2009) // in vitro
10.Evidence-based Complimentary & Alternative Medicine
Dynamized Preparations in Cell Culture (2009) FULL TEXT //Carcinosinum 200C,Conium,Lycopodiumactivates beneficial gene p53 which provides defense against tumour/cancer
11. The Journal of Alternative and Complementary Medicine
Variation in Fourier transform infrared spectra of homeopathic potencies (2005) FULL TEXT // FTIR spectra of Nux Vomica 30c, Lycopodium 30c, Santonin 30c, Cina 30c distinguishes from solvent, sugar globule soaked in homeopathic medicine retains its specific spectral absorption properties
Cadmium 15c-20c exhibit a biologic effect on cell cultures of normal primary lymphocytes (2006) // in vitro
12. Alternative Therapies in Health and Medicine
The similia principle as a therapeutic strategy: a research programme on stimulation of self-defense (1997) FULL TEXT //scientific evidence of ‘principle of similars’
13. Clinical and Developmental Immunology
Traummel S activates immunocytes (2004) FULL TEXT
14. Subtle Energies and Energy Medicine
Homeopathic Potencies Identified By A New Magnetic Resonance Method (2006)// two methods: modified photomultiplier method, tesla coil method
15. Journal of Molecular Liquids
High dilutions of histamine distinguishable using NMR (2009)
16.Interdisciplinary Sciences: Computational Life Sciences
Nanostructures in highly diluted biological samples of bacteria and virus DNA sequence produces electro-magnetic signals (2009) FULL TEXT
17. Physica A
Low temperature Thermo-luminescence of ultra-high dilutions of lithium chloride 15c & Natrum Mur 15cusing heavy water (2003) FULL TEXT // distinguishing one homeopathic medicine from another,the emitted light wasspecific of the original salts dissolved initially
18. Complementary Therapies in Medicine
“Potentized homeopathic drugs act through regulation of gene expression (1997) // homeopathic substances have the capacity to interact with the genetic blueprint and deliver their benefits by increasing the expression of genes that synthesise health promoting proteins i.e. homeopathic medicines activate genes. http://www.sciencedirect.com/science/article/pii/S0965229997800908
19. L’ Homéopathie française
The action of Belladonna and Ferrum phosphoricum on the chemiluminescence of polynuclear neutrophils (1983) // Belladonna and Ferrum phosphoricum in 5c potency significantly inhibits the release of oxygenated free radicals involved in the initiation and maintenance of inflammatory phenomena.
20. British Homoeopathic Journal
Belladonna, Hepar sulphur, Pyrogenium, Silicea and Staphylococcin in Mother Tincture modifies the white blood cell movement (1982) // in vitro
Managanum phosphoricum 6x, Acidum malicum 4x and Acidum fumaricum 4x regulate the oxidative metabolism and adhesion function of human neutrophils (1993) // in vitro
21.Arzneimittelforschung
Homeopathic medicines in 1X to 30X potencies enhanced the phagocytic activity of granulocytes (1986) // in vitro & in vivo
22.Phytotherapy Research
Combination of Aconitum and lachesis in 1X potency enhanced the phagocytic activity of granulocytes upto 390% (1994) // combination remedy
23.Histology and Histopathology
Scanning electron microscopy to investigate the structure of platelets of HIV patients treated with Canova (2009) // combination remedy
24.Forschende Komplementärmedizin und Klassische Naturheilkunde
Effect of homeopathic plant extract solutions on the cell proliferation of human cutaneous fibroblasts (2003) // in vitro
25.Inflammation research
Zeel comp. N as well as its individual ingredients (Arnica montana, Sanguinaria canadensis and Rhus toxicodendron) inhibits the production of Leukotriene B4; Solanum dulcamara Q inhibits the production of Prostaglandin E2 (2004) FULL TEXT // anti-inflammatory, combination remedy, in vitro https://docs.google.com/file/d/0B0b69JqzK_44YWRseHVvNnYyNXlqOUxmYUh1UXBMNHJsLW04/edit
26. Integrative Cancer Therapies
Effect of Sabal serrulata on prostate cancer growth (2006) // in vitro
27. Environmental Toxicology and Pharmacology
Hepeel prevented cadmium chloride-induced cell death in liver cells (2009) // China Q and Nux moschata Q protected against loss of glutathione and lipid peroxidation. Carduus marianus Q demonstrated anti-apoptotic effects. in vitro, combination as well as single
Hahnemann’s Contribution
28. Zeitschrift für Praktischen Medizin
An essay on a new principle for ascertaining the curative powers of drugs & some examinations of the previous principle,volume 2, parts 3 & 4, pages 391-439 & 465-561, Germany, 1796 // He came up withPrincipleof similars:Like cures like
29. Allgemeiner Reichsanzeiger
Spirit of the Homoeopathic Doctrine of medicine , vol. 2, Mar. 1813 // He said Man is a “biological whole”. No single part by itself represents the human being nor can manifest itself independently [from the others] [20].
30.The British Journal of Homoeopathy
C. SUPER-AVOGADRO DILUTION RESEARCH
(Dilutions beyond Avogadro number/High Dilutions)
1.Complementary Therapies in Medicine
The in vitro evidence for an effect of high homeopathic potencies—A systematic review (2007) FULL TEXT // 73% of 67 in-vitro experiments published in 75 publications showed specific effects with high dilutions including 68% of high quality experiments (SAPEH score>=6)
Homeopathy, sensation of well-being and CD4-levels (1998) // homeopathy improves sensation of well-being, provided evidence of ultra-high dilutions and may affect CD4 levels
2. Interdisciplinary Sciences: Computational Life Sciences
Nanostructures in highly diluted biological samples of bacteria and virus DNA sequence produces electro-magnetic signals (2009) FULL TEXT
3.Material Letters
Ultra dilute solutions have remarkable biological properties (2008) FULL TEXT //ultra-dilutions, like homeopathic remedies, do indeed contain stable and unique molecular structures with recognizable properties
4. Physica A
Low temperature Thermo-luminescence of ultra-high dilutions of lithium chloride 15c & Natrum Mur 15cusing heavy water (2003) FULL TEXT // distinguishing one homeopathic medicine from another,the emitted light wasspecific of the original salts dissolved initially
5.Nonlinear Biomedical Physics
Influence of diluted mediators on fungal laccase activity (2009) FULL TEXT // bi-phase action, in vitro & in vivo
6. Journal of Molecular Liquids
High dilutions of histamine distinguishable using NMR (2009) FULL TEXT
7. Homeopathy
Medicines beyond 12C retains nano-grams of fine nano-particles of original starting material (2010) FULL TEXT
Delayed luminescence of high homeopathic potencies on sugar globuli (2008) FULL TEXT
Distinguishing Natrum Mur 30 from water by High voltage plasma (2008)// electrical impedance of Natrum Mur 30c differ from water
Individualised Homeopathy for treatment of symptoms of oestrogen withdrawal in breast cancer patients (2003) // n=45, Primary symptoms such as hot flushes,Primary symptoms changed from 7.8 to 5.4, and from 7.2 to 4.1 (p<0.001)
8. The Journal of Alternative and Complementary Medicine
Gas Discharge Visualization Evaluation of Ultramolecular Doses of Homeopathic Medicines (2003) // distinguishing homeopathic medicine from solvent using Bio-Electro-graphy: Dynamic Electrophotonic Capture
9. Subtle Energies and Energy Medicine
Homeopathic Potencies Identified By A New Magnetic Resonance Method (2006) //two methods: modified photomultiplier method, tesla coil method
10. Medical Hypothesis
Biomathematical modeling for diluted drugs (2003) FULL TEXT http://www.neohahnemannism.com/Neohahnemannism_files_files/Biomathematical%20model.pdf
11.Journal of Head Trauma and Rehabilitation
Homeopathic treatment of mild traumatic brain injury(1999) // n=60, t=4 months, individualised (1 of 18 ) medicine (super-avogadro), Patients rated improvement of symptoms severity score as 0.40±0.57 in homeop. patients and 0.13±0.39 in placebo patients, a significant improvement in functional assessment in favour of homeopathy, OR=1.98 http://www.ncbi.nlm.nih.gov/pubmed/10671699
Hahemann’s Contribution
12.Zeitschrift für Praktischen Medizin
Cure and prevention of scarlet fever, 1801 // His discovery of the prophylactic properties of Belladonna in scarlet fever. His dose: 1/24,000,000 i.e. 0.0416 nanograms of Belladonna, to repeat the dose every 72 hrs. This is the first recorded nano dose of medicine used in treatment of any disease. Thus Hahnemann can be attributed as The Father of Nano Medicine
On the Power of Small Doses of Medicine in General and of Belladonna in Particular “, Vol. 13, part 2, p. 153-159, Jan. 1801.
discussions:
http://lkm.fri.uni-lj.si/xaigor/slo/znanclanki/instrumental.htm (1999) FULL TEXT // kali Iodide
http://www.high-dilutions.net/VersionAn
E1. HOMEOPATHIC PATHOGENETIC TRIALS/DRUG PROVINGS
1.Homeopathy
Double-blind Placebo-controlled homeopathic patho-genetic trials (2006) FULL TEXT
Chelidonium majus 6c produced changes in blood globulin in healthy provers (1989)
Reproving of Cantharis 30c: blinded randomised placebo-controlled trial (2004) n=11
Reproving of Plumbum metallicum 30c: DBRPCT (2005)
2.Forschende Komplementarmedizin
Homeopathic patho-genetic trials produce specific symptoms different from placebo (2009) FULL TEXT // homeopathy differs from placebo
3. Trials
Protocol for a phase 1 homeopathic drug proving trial (2010) FULL TEXT
4. Journal of Psychopharmacology
Homeopathic pathogenetic trials produce more specific than non-specific symptoms (2008) //double-blind placebo-controlled study, homeopathic ozone
5. British Homoeopathic Journal
Iodum 12x produced changes in blood electrolyte and thyroid harmone in healthy provers (1988)
Effect of Strophantus Hispidus 30c on heart rate variability (1999) // n=10, single-blind
E2. DRUG STANDARDISATION
1. Ancient Science of Life
Pharmacognostic studies of Thuja (1999) FULL TEXT
Physico-chemical profile of Bixa and Lawsonia (2001) FULL TEXT
2. Homeopathy
Ethanol concentrationin the preparation of mother tinctures of vegetable origin (2002)
F2. TRIPLE-BLIND RANDOMISED PLACEBO CONTROLLED TRIAL
1.Journal of Psychosomatic Research
Efficacy of individualised homeopathic treatment for chronic fatigue syndrome (2004) FULL TEXT //n=93, t=6 months, homeopathy significantly improved function and fatigue compared to placebo, p=0.04 Weak but equivocal evidence that the effects of homeopathic medicine are superior to placebo, OR=1,47, Jadad score=5 https://docs.google.com/file/d/0B0b69JqzK_44MzR1Y1ZXQlgyRXJpeEQ3OHJsYk1XWl8xdjEw/edit
F3.DOUBLE-BLIND RANDOMISED PLACEBO-CONTROLLED TRIAL
1. Lancet
Grass Pollens in 30c potency vs placebo for hay fever (1986)// n=144, Symptoms severity (VAS) decreased 17.2±28.8 mm in homeop. patients and -2.6±33.6 mm in placebo patients, p=0.018 in favour of homeopathy, Linde Quality=5
Is evidence for homoeopathy reproducible? (1994) //potentised allergans in 30c potency on 28 allergic asthma patients does more than placebo, Symptoms severity (VAS) decreased 7.2±3.2 mm in homeop. patients and -7.8±3.0 mm in placebo patients, severity of symptoms (p=0.003), vital capacity (p=0.03), Jadad score=4, Linde Quality=5
2. International Journal of Oncology
Ruta 6 induces cell deaths in brain cancer cells: A novel treatment for human brain cancer (2003) FULL TEXT // ruta 6c in combination with calarea phos 3x, in vitro and in vivo
Cytotoxic effects of ultra-diluted remedies on breast cancer cells (2010) FULL TEXT // in-vitro study: Carcinosin 30c, Phytolacca Decandra 200c, Conium 3c and Thuja 30c caused death of 5000 MCF-7 and MDA-MB-231breast cancer cell lines in the laboratory for periods of between 1 to 4 days (experiment repeated 3 times), similar to the effect of chemotherapy, but without affecting normal cells.Carcinosin and Phytolacca—achieved up to an 80% response indicating that they caused cancer cell death. By comparison, placebo solvent achieved only 30%. The effects of Carcinosin and Phytolacca were as powerful as Paclitaxel (Taxol)
3.Rheumatology
Improved Clinical Status in Fibromyalgia patients treated with homeopathic remedies Vs Placebo (2004) FULL TEXT // n=53, t=3months, individualised41 remedies in LM potency, significant fewer tender points compared to placebo, 25% improvement in tender point pain on palpation (p=0.008), improvement in Fibromyalgia score (P<0.05) and Global health rating (p<0.05), improvement in McGill Affective pain score compared to placebo (p<0.01), significant improvement in quality of life and depression, Jadad score=5, SIGN=GOOD
4.Chest
Kali bichromicum 30C for Chronic Obstructive Pulmonary Disease in critically ill patients in ICU (2005) FULL TEXT // n=50,5 globules of homeopathic medicine or placebo twice daily, significantly less tracheal secretions at day 2 (p<0.0001 in favour of homeopathy) and significantly less stay in ICU (p<0.0001 in favour of homeopathy)
5. British Medical Journal
Rhus Tox 6c thrice daily vs placebo for fibrostis (1989) FULL TEXT // fibromyalgia (earlier known as fibrositis) (Pain & Inflammation in muscles,n=30, non-individualised study, RT given thrice daily, significant fewer tender points compared to placebo (p<0.005), improvement in pain and sleep compared to placebo (p=0.0052), Therapeutic success was observed in 11/30 homeopathy patients and 4/30 in placebo group, this study got replicated in above rheumatology journal (2004), Jadad score=4, Linde Quality=3
Potentised Allergan 30c Vs Placebo in allergic rhinitis (2000) FULL TEXT // n=51,inhalant Allergan 30c, Mean nasal inspriatory peak airflow improved by 21 % in homoepathic patients and 2 % in placebo patients, Jadad score=5, “It may be time to confront the conclusion that homeopathy and placebo differ..”
6. British Journal of Clinical Pharmacology
Oscillococcinum 200c in the treatment of influenza (1989) FULL TEXT //(n=487, 237 treated and 241 on placebo), if taken twice daily for 5 days significantly increased the rate of cure within two days, absence of symptoms at 48 hours, relative risk estimate significantly favour homeopathy (p=0.048), no pain and no fever (p=0.048), recovery rate (headache, stiffness, articular pain, shivering reduction) at 48 hours better in homeopathy group (p=0.032)
Homeopathic therapy in rheumatoid arthritis (1980) FULL TEXT //n=43, t= 3months, significant relief in 19/23 (82%) homeopathy patients and 5/23 (21%) placebo patients, individualized medicine, Linde OR=10.85
7.Phlebology
“Complementary Treatment of Varicose Veins: A Randomised, Placebo-controlled, Double-blind Trial” Edzard Ernst, T. Saradeth, K.L. Resch, 1990, 157-163.
Three doses of a poikien (combination remedy of eight homeopathic medicines)were given to 61 patients daily for 24 days. Measures were venous filling time, leg volume, and subjective symptoms. The study found that venous filling time improved in those given the homeopathic medicines by 44%, while it deteriorated in the placebo group by 18%. Other measures also had significant differences.Linde OR=2.6 in favour of homeopathy, Linde Quality=1
8. British Journal of Podiatry
Ruta Graveolens 30C for the treatment of pain in plantar fasciitis (foot) (2000) // n=14
9.European Journal of Paedretics
Lycopodium, Calcarea Carbonica, Sulphur, Belladonna, Causticum and Phosphorous forAttention Deficit Hyperactivity Disorder (2005) FULL TEXT // individualised medicine (LM potency), crossover study, 63 of 83 children (6-16 years) responded to homeopathy, those 63 were then randomised to receive either homeopathic medicine or placebo for 6 weeks, homeopathy found significantly superior to placeboin behavioural and cognitive functions in 10 days, p<0.0001, CGI Index improved by 63% in the long-term follow-up in 53/63 patients, SIGN=good, Jadad score=5
10. Archives of Facial Plastic Surgery
Effect of Homeopathic Arnica montana on Bruising in Face-lifts (2006) FULL TEXT// n=129, Arnica every 8 hours for 4 days post-operation, significant difference in favour of homeopathy on day 1 (p<0.005) and day 7 (p<0.001), sign level=1-
11. BMC Cancer
TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in cancer patients (2001) FULL TEXT // n=15, age=3-25 years,symptom severity as 10.4 in homeop. patients and 24.3 in placebo patients, p<0.01
12.Applied Health Economics & Health Policy
Sinfrontal (Cinnabaris 4X, Ferrum Phos 3X, etc) in the treatment of maxillary sinus (sinus + tooth pain) (2009) // ENT and respiratory tract infections
13.Pediatrics
Treatment of acute childhood diarrhea with individualised homeopathic medicine (1994) FULL TEXT // n=81,18 different remedies in 30C potency, one dose after every unformed stool for 5 days: Podophyllum, Chamomilla, Arsenicum album, Calcarea carbonica, sulphur, Mercurius vivus, Pulsatilla, Phosphorus, China, Gambogia, Aethusia, aloe, belladonna, Bryonia, Colchicum, Croton tiglium, Dulcamara, Nux vomica, significant effect for duration of diarrhea (p=0.048) and number of daily unformed stools (p<0.05) compared to placebo , Time to normal stools was 3.0±1.9 d in homeop. patients and 3.8±1.7 d in placebo patients, Jadad score=5, Linde Quality=5
14. Journal of Dermatological Treatment
Homoeopathic treatment of leg ulcers (1997) //n=53, t=4.2 weeks, Sulphur 6, Silicea 6 and Carbo Veg 6, Ulcer size improved 58.7±44.5 % in homeop. patients, 10.3±42.7 % in placebo patients and -4.6±89.1 % in untreated patients
15. The Science of the total Environment
Arsenicum Album 30C for arsenic toxicity: Evidence-based findings (2007) FULL TEXT //n=43, 18 untreated, 22 on homeopathy an 17 on placebo
16. Annals of Pharmacotherapy
Treatment of allergic rhinitis with potentised allergan in 30c potency and placebo(2005) // n=34, t=4 weeks, Jadad score=5
17. Explore: The Journal of Science and Healing
Sinfrontal vs placebo for Acute Maxillary Sinusitis (Sinus + tooth pain) (2007) //n=113, combination remedy
18.European Journal of Clinical Pharmacology
Homeopathic gel for redness/rash & lump on the skin due to mosquito bite (1995) //68 people were bitten at least 3 times by mosquitoes. One of the bites was treated with an after-bite gel containing homoeopathic ingredients, another of the bites was treated with a placebo gel, and the third bite remained untreated. The active gel provided results that were significantly superior to the placebo or no treatment.
19. Hals, Nasen und Ohrenärzte
Homeopathy in acute rhino-sinusitis (2007) FULL TEXT // n=144, t=21 days, homeopathic treatment resulted in freedom from complaints in 90.3% of the patients & improvement in a further 8.3%, whereas in placebo group, the complaints remained unchanged or became worse in 88.9% of the patients, p>0.0001, combination remedy sinfrontal
20. Journal de gynécologie, obstétrique et biologie de la reproduction
Treatment of pain in post-partum women who elected not to breastfed with Apis 9c and Bryonia 9c(2001)// n=71, 5 pills twice daily for 10 days
21.Der Kassenarzt
Tonsilotrena for tonsillitis (2006)
22. Arzneimittel-Forschung
“Homoeopathische kombination bel vertigo and nausea”, C.F. Claussen, J. Bergmann. G. Bertora .and E. Claussen, 34 (1984):1791-98. // vertigoheel, combination remedy
Bronchiselect for treatment of bronchitis(1997) // n=258, combination remedy
24.Allergologie
Treatment of pollinosis with the homeopathic preparation Galphimia Glauca2c and placebo (1990)// n=243, average t=33 days, odds ratio=2.19 in favour of homeopathy
25.Aktuelle Rheumatologie
‘Rheumaselect’ vs placebo for chronic Rheumatoid poly Arthritis (1991) // combination remedy, n=111, Jadad score=3
26.Journal of Head Trauma and Rehabilitation
Homeopathic treatment of mild traumatic brain injury (1999) // n=60, t=4 months, individualised(1 of 18 ) medicine (super-avogadro), Patients rated improvement of symptoms severity score as 0.40±0.57 in homeop. patients and 0.13±0.39 in placebo patients, a significant improvement in functional assessment in favour of homeopathy
27.American Journal of Therapeutics
Treatment of Psoriasis with Reliéva (2006) // n=200, combination remedy
28.Sleep and Breathing
Combination remedy in management of snoring (1999) FULL TEXT // snore stop, n=90,Rated improvement in homeopathy group was significantly better (35/44) compared to placebo group (21/46) https://docs.google.com/file/d/0B0b69JqzK_44bmk3MFg5MXZ3MFpoRldfU1J0bjJfcDI4Y1kw/edit
HOMEOPATHY JOURNALS:
1.Homeopathy
The research evidence base for homeopathy (2003) FULLTEXT // 50 of the 93 studies favours homeopathy in 8 medical conditions: diarrhoea, fibrositis, hayfever, influenza, pain, side-effects of radio- or chemotherapy, sprains and upper respiratory tract infection
Effects of homeopathic treatment on itching of skin (pruritis) in haemo-dialysis patient (2003) // n=20 on dialysis for 6 months, main outcome: >50% reduction in pruritis score, Pruritis score was 38 (+/-33) in hom. treated patients and 57 (+/-39) in placebo group, after 60 days, itching reduced by 49% in 30 days, individualised medicine, OR=3.5,http://www.ncbi.nlm.nih.gov/pubmed/14587682
Homeopathic treatment in ICU patients with severe sepsis (2005) FULL TEXT //67 patients given 200c potency of individualised medicine every 12 hours for 180 days, patient survival significantly higher with homeopathy compared to placebo(75.8% vs 50%, p=0.043, OR=3.13
Homeopathic & antibiotic treatment strategies in recurrent acute rhinopharyngitis (2005) // Inflammation of the mucous membranes of nose & throat.In 499 patients homeopathy yielded significantly better results than antibiotics in terms of effectiveness, number of complications and quality of life
Arnica montana 30C for post-tonsillectomy analgesia (2007) FULL TEXT // pain after tonsils removal,n=111, Arnica group had a significantly larger drop in pain score from day 1 to day 14 (28.3) compared to the placebo group (23.8)
Osteo-arthritis before and after homeopathic treatment (2008) FULL TEXT
Chronic Insomnia: Efficiacy of homeopathic simillimum (2010) FULL TEXT //n=30, t=4 weeks, individualised medicine, total number of hours of sleep per week, p<0.05; Severity of Insomnia Index, p<0.0001
Effect of Arnica 30X on muscle soreness in marathon runners (2003)// muscle soreness immediately after a marathon run was lower in the Arnica treated group than in those treated with placebo (p=0.04)
Reproving of Plumbum metallicum 30c: DBRPCT(2005)
2. British Homoeopathic Journal
Efficacy of China rubra 9C for complications in patients on chronic kidney dialysis (1992) // n=35, Statistically significant improvements of weakness, lethargy and headache, Linde Quality=3
Immunoglobin Relationship in Patients with Cirrhosis of the Liver Before and After treatment with Zincum metallicum 5C (1994) // 10 people suffering from Zinc deficiency as determined by atomic absorption spectrophotometry showed a substantial improvement in zinc levels
Oscillococcinum in patients with influenza (1998) // n=372, 3 doses per day for 3 days, no spinal pain at 48 hours (p=0.03), no muscle pain at 48 hours (p=0.01), no articulate pain at 48 hours (p=0.009), Significant effect of homeopathy over placebo in duration of influenza (p=0.0257)
Individualised Homeopathy for diseases of the lymph nodes in HIV Stage 2 & 3 infected people (1999) FULL TEXT // n=100, age=18-50 years, p=0.04, Phosphorus, Lycopodium, Pulsatilla, Nux vomica was beneficial (significant difference in CD4 cell count whereas no change in placebo group )for symptomatic HIV sufferers, immunity raised
Belladonna 7C and X-Ray 15C for treatment of radio-therapy induced dermatitis and skin darkening in breast cancer (2000)// n=66, t=10 weeks, Belladonna 3 granules twice daily and X-ray three granules once daily, significant reduction in total severity of skin reaction in the homeopathy group during recovery (p=0.05) compared to placebo, less hyperpigmentation in homeopathy group (p=0.05), significant decrease in skin heat in homeopathy group compared to placebo (p=0.011) Jadad score=4
Individualised Homeopathic treatment of migraine (2000)n=68, Neurologist assessment showed a 60% decrease in attack frequency of treatment group compared to 42% of the placebo, p=0.04, http://www.ncbi.nlm.nih.gov/pubmed/10703903
Potent placebo or potency?A model using homeopathically prepared pollens 30c in hayfever (1985) // n=39, Jadad score=3
3.Asian Journal of Homeopathy
To investigate the effectiveness of homeopathy in medical primary care in upper and lower respiratory tract complaints, 01 Feb 2008, pp. 3-19
4.American Journal of Homoeopathic Medicine
Homeopathic treatment of dental neuralgia by Arnica and Hypericum., Albertini H, Goldberg W, Sanguy B, Toulza CL., 1985, 3, pp. 126-129. // 60 people received either 4 pilules of Arnica 7C alternated with 4 pilules of Hypericum 15C every 4 hours or placebo administered in the same way. Pain levels were assessed over 3 days from the beginning of the trial. It was found that 12 of the 30 people who received the placebo had a positive response to this intervention, and 23 of the 30 people (76%) given the homeopathic medicines responded positively to these.
others: Central Council for Research in Homeopathy, Govt of India
Clinical research (1979-1992)
Collaborative Research (1988-2007)
CAM JOURNALS
1. Evidence-based Complementary & Alternative Medicine
Arsenicum album 30C and 200 C alters antinuclear antibody (ANA) titre in people living in high-risk arsenic contaminated areas (2006) FULL TEXT // n=69, 26 untreated, 26 on homeopathy and 17 on placebo, correction of arsenic-induced haematological changes such as total count of RBC, WBC, PCV, Hb, ESR and blood sugar level
2. The Journal of Alternative and Complementary Medicine
Individualised Homeopathic treatment of acute childhood diarrhoea (2000) // n=116, t=5 days, replicated study, Nepal,19 different remedies in 30C potency, one dose after every unformed stool for 5 days; 5 most common: Podophyllum, sulphur, Arsenicum album, Calcarea carbonica, Chamomilla , significant effect for duration of diarrhea (p=0.04) and number of daily unformed stools (p=0.02) compared to placebo, Time to normal stools was 3.5 d in homeop. patients and 4.2 d in placebo patients, Jadad score=5 http://www.ncbi.nlm.nih.gov/pubmed/10784270
Homeopathy vs placebo for menopausal symptoms in stage 1-3 breast cancer patients (2005) // n=55, t= 1 year,at least 3 episodes of hot flushes per day for at least 1 month, significant improvement in quality of life, Jadad score=5, [significant improvement in both homeopathy group compared to placebo, p<0.03 for combination remedy (Hyland’s Menopause) and p=0.02 for individualized homeopathy (35 remedies) (given once or twice a month)], significant improvement in hot flush severity in combination group over placebo (p=0.01), significant improvement in total number of hot flushes in combination group over placebo (p=0.006), OR=3.84
3. Complementary Therapies in Medicine
Homeopathy, sensation of well-being and CD4-levels (1998) FULL TEXT //n=36, Individualised homeopathy improves sensation of well-being, provided evidence of ultra-high dilutions and may affect CD4 levels, Mental (p=0.28) and physical (p=0.002) symptoms were in favour of homeopathy
Effects of the Arnica 30X vs placebo on 1995 Oslo marathon runners (1998) FULL TEXT //// n=71, reduces muscle soreness immediately after the marathon (p=0.017). Severity score after running was 6.27±1.85 in homeop. patients and 7.28±2.48 in placebo patients, Sign level=1+, Arnica 30x 5 pills twice a day for 3 days
Arnica montana 6c & Bellis perennis 30c on post-partum bleeding (2005) // bleeding after delivery, t= 72 hours, Hemoglobin level dropped in control group, but remained stable in the treatment group (statistically significant).
Arnica 30x vs placebo for patients receiving knee ligament reconstruction surgery (2006) // inflammation, n=57,116 on homeopathy and 111 on placebo, p=0.019, Oxford Quality score=5/5
4.Alternative Therapies in Health and Medicine
Use of Arnica 6x to relieve pain after carpal-tunnel release surgery (2002) // n=37, t= 2 weeks,3 times per day, Oxford Quality score=5/5
5.Alternative Medicine Review
Kali Bromatum 1X, Natrum Bromatum 2x, Nickel Sulfate 3X, Natrum Mur 6X vs placebo for dermatitis of scalp and dandruff (2002) FULL TEXT // n=41, t=10 weeks, Symptom severity score (at 5 weeks) improved 35.2±35.5 % in homeop. patients and 8.4±35.2 % in placebo patients, p=0.03
6.Forschende Komplementarmedizin
Aconitum 30C differs from placebo(2009)
Efficacy of stibium (antimony) 6X on blood coagulation (2009) // n=30, pro-coagulatory effect in bleeding disorder
Efficacy of the Euphorbium compositum-S nasal spray in sinusitis(1994) //n=155, Score for treatment severity was 1.37±0.30 in homeop. patients (n = 53) and 1.44±0.34 in placebo patients (n = 51), Linde quality=5
7.Forschende Komplementärmedizin und Klassische Naturheilkunde
Euphorbium, Pulsitilla & Luffa for viral infection of respiratory tract, Influenza A virus & rhino virus (2001) FULL TEXT //Euphorbium Compositum
Efficacy of Phyto-Hypophyson L in female for sterility & infrequent mensuration (2000) //A study of 67 women showed 57 percent improvement in fertility. Homeopathic treatment seemed to influence several factors including regulation of the menstrual cycle, regulation of hormones and enhancing ovulation
8. Ärztezeitschrift fuer Naturheilverfahren
Effect of Arnica montana 6 cH on edema, mouth opening and pain in patients submitted to extraction of impacted third molars (2005) FULL TEXT
9.Phytomedicine
Galphimia glauca 4X in treatment of pollinosis (1995) FULL TEXT // n=164, https://docs.google.com/file/d/0B0b69JqzK_44cV9FVUw5R3ZpOUJxZ1FkeXVxN1pjWXZkRkQ0/edit
F4. DBRCT (other-than-placebo controlled)
1. Archives of Otolaryngology- Head & Neck Surgery
VertigoHeel Vs conventional treatment of vertigo(1998) FULL TEXT // n=105, Statistical Significant results with homeopathy as well as betahistine HCL
2. British Homeopathic Journal
Efficacy and safety of a homeopathic gel Spiroflor SRL in the treatment of acute low back pain(2001) FULL TEXT //SRL (Symphytum, RhusTox, Ledum Pal) is equally effective as Cremor Capsici Compositus FNA but has better safety profile, n=21, high quality study
3.Evidence-based Complementary & Alternative Medicine
Homeopathic LM potencies Vs Fluoxetine for Depression(2009) FULL TEXT //n=91, individualized homeopathy, 1 drop thrice a week, 20 mg Fluoxetine HCL daily, sign level=1++, Homeopathy not inferior to fluoxetine (Prozac) but had a better safety profile. Higher percentage of patients treated with fluoxetine reported troublesome side effects and there was a trend toward greater treatment interruption for adverse effects in the fluoxetine group compared to homeopathy
4. The Journal of Alternative and Complementary Medicine
Arnica montana 4X for Healing of Wounds After Hallux Valgus (foot) Surgery Compared to Diclofenac 50 mg(2008) //n=88, t= 4 days, Arnica 10 globules 3 times a day for 4 days, Diclofenac 50 mg 3 times a day for 4 days, Both Arnica and Diclofenac therapeutically equivalent in wound irritation (p=0.049), swelling and patient mobility, arnica 60 % cost-effective than diclofenac, Arnica better tolerable in Homeopathy group (intolerance of 244 in homeopathy group compared to 9/44 in Diclofenac group), sign level=1-
VertigoHeel for treatment of Vertigo(2005)// combination remedy for atherosclerosis-related vertigo, n=170, t=6 weeks, control: Ginkgo Biloba, Vertigoheel was not inferior to G. biloba
5. Forschende Komplementärmedizin und Klassische Naturheilkunde
Comparing Luffa compositum-Heel nasal spray with cromolyn sodium spray in the treatment of allergic rhinitis(1999) FULL TEXT //n=146, combination remedy Homeopathic Nasal Spray containing Luffa, Galphimia, Histamine and Sulphur is as efficient and well tolerable as conventional therapy as Cromolyn Sodium
F5. Single-Blind Randomised Placebo Controlled Trial
1. Homeopathy
Individualised Homeopathic treatment of mouth ulcer(2009) FULL TEXT// n=100, t=6 days, two doses, pain intensity and ulcer size significantly lower in homeopathy group compared to placebo, P<0.05
Effects of homeopathic treatment on salivary flow rate in patients with oral drynessof the mouth (2005) // n=28, t=12 weeks, 13/15 patients in homeopathy group experienced a significant relief of xerostomia whereas no such effect was found in the placebo group (0/13). Following this, those on placebo were switched to homeopathic medicine, after which all experienced relief from dryness of the mouth.
F6. Randomised Placebo-Controlled Trial
1.International Review of Allergology and Clinical Immunology
Gripp-Heel for prevention of influenza (1999) FULL TEXT //n=124, Increases in antibody responses were higher in homeopathy patients than in placebo patients
F7. RCT (other-than-placebo controlled)
1. Journal of Clinical Oncology
Phase 3 RCT of Calendula compared with trolamine for prevention of dermatitis during radiotherapy for breast cancer (2009) FULL TEXT //n=254, p<0.001, reduction in high energy radiation-induced pain, superior to trolamine https://docs.google.com/file/d/0B0b69JqzK_44NVhRVWxnWl93eEVyRWZCN0tGbmcyejRwWDJN/edit
2.Complementary Therapies in Medicine
Calcarea Carbonica 30c, Pulsatilla 30c and Sulfur 30c for the prevention of upper respiratory tract infections (2005) // 2 pills for 2 days per week for 12 weeks, n=169. The difference in the median number of days with URTI symptoms was statistically significant with 8 days in the homeopathic group and 13 days in the control group (p = 0.006), Jadad score=5, http://www.ncbi.nlm.nih.gov/pubmed/16338192
3. Zeitschrift für Orthopädie und ihre Grenzgebiete
Efficacy of homeopathy in the treatment of chronic low back pain(2002) // RCT, n=43
4. Arzneimittel-Forschung
Comparison of acetylsalicylic acid with Eupatorium perfoliatum 2X in treatment of common cold (1981) //// n=53, Symptom severity score (4d) was 6.1±3.6 in homeop. patients and 6.4±3.6 in standard patients, Linde Quality=2, homeopathy equals conmed
F8. DBPCT
1. Journal of Psychopharmacology
Homeopathic pathogenetic trials produce more specific than non-specific symptoms(2008)
2. British Journal of Clinical Pharmacology
Effect of Nux Vomica 30 and Coffea Cruda 30on polysomnographic sleep of young adults(2010) FULL TEXT // insomnia https://web.archive.org/web/20131204062234/http://www.homeopathyoz.org/downloads/PolysomnographicTestingOfInsomnia-22Mar2010.pdf
3. British Homoeopathic Journal
Arnica, Bryonia & Rhus Tox for fibromyalgia(1986) // n=24, t=3 months,significant improvement in pain (p<0.05) and sleep (p<0.05), Jadad score=3
Stramonium 200c and Hyoscyamus 200c for Attention Deficit Hyperactivity Disorder(1997) FULL TEXT // n=43, p<0.05, Mean response scores were 1.00 in homeop. patients and 0.35 in placebo patients, Jadad score=2, medicine 6 times a day for upto 5 days
F9. DOUBLE-BLIND STUDIES
1.MicroVascular Research
Micro-circulatory effects of VertigoHeel on vertigo (2005) FULL TEXT // n=32, t=12 weeks
2.British Homoeopathic Journal
Mustard Gas 30 as prophylactic and Rhus Tox 30c for treatment of burns and skin lesions due to mustard gas (1943) http://www.jameslindlibrary.org/illustrating/records/report-on-mustard-gas-experiments-glasgow-and-london/whole_articles
3. Homeopathy
Treatment of hyperactive children (2006) FULL TEXT
F10. PRIMARY HEALTH CARE STUDIES (OBSERVATIONAL/COHORT/PILOT STUDIES)
1. BMC Public Health
Homeopathic medical practice (2005) FULL TEXT // (Chronic) Disease severity (p<0.001) and quality of life demonstrated marked and sustained improvements following homeopathic treatment in 3981 patients for 2 years, Conditions treated were allergic rhinitis in men, headache in women, and atopic dermatitis in children, cohort study
How healthy are chronically ill patients after eight years of homeopathic treatment? (2008) FULL TEXT // 103 swiss and german clinics,73% of 3709 patients followed up for 8 years, p<0.001,quality of life increases, disease severity decreases from 6.2 at baseline to 2.9 at 2 years to 2.2 at 8 years. For children, a reduction from a baseline disease severity of 6.1 to 2.1 at 2 years was noted and then to 1.7 at 8 years.
2.Explore: The Journal of Science and Healing
Viburcol (Chamomilla, Belladonna, Calcarea carbonica, Dulcamara, Plantago major, and Pulsatilla) for treatment of fever (2005) // n=198 in 38 Belgian clinics,febrile symptoms such as fever, cramps, disturbed sleep, difficulty eating or drinking, crying, Viburcol as effective as acetaminophen but better tolerable
Traumeel S ointment for tendon injuries (2005) // n=253, traumeel superior to 1% diclofenac gel
Asclepias vincetoxicum & Sulphur for treatment of upper respiratory infections associated with common cold (2006)
3.The European Journal of Heart Failure
Efficacy of homeopathic Crataegus & Spigelia for mild cardiac insufficiency (2003) FULL TEXT
4.Pediatrics International
Spascupreel for treatment of Gastro-intestinal crampsand spasms in children (2007)// cohort study, n=204, t=1 week, children were given either spascupreel or hyoscine butylbromide, both found equally good
5.Scientific World Journal
Avena Sativa 2X, Passiflora Incarnata 2X, Zincum Valerianicum 4X, Coffea Cruda 12X for treatment of Insomnia (2008)// combination remedy Neurexan vs Valerian, 89 clinics, t=28 days, n=409, less daytime fatigue in homeopathic patients 49% vs 32% in valerian, duration of sleep at 8, 12, 14 days and daytime fatigue (both significantly in favour of homeopathy), SIGN level=2-, http://downloads.hindawi.com/journals/tswj/2008/689282.pdf
Avena Sativa 2X, Passiflora Incarnata 2X, Zincum Valerianicum 4X, Coffea Cruda 12X for treatment of nervousness/restlessness (2009)FULL TEXT // Neurexan (combination remedy), other-than-placebo controlled: Valerian The summary score for nervousness/restlessness was reduced in the Neurexan group by 11.5 ± 7.3 score units. In the valerian group, the summary score was reduced by 9.0 ± 6.6, http://downloads.hindawi.com/journals/tswj/2009/563750.pdf
6.International Journal of Clinical Practice
Gripp-Heel (Aconitum napellus 4X, Bryonia alba 4X, Eupatorium perfoliatum 3X, Lachesis, Phosphorous) for viral infections (2004) FULL TEXT //n=485, 78.1% of people found it effective compared to 52.2% of those using conventional medicine
7.Journal of Hellenic Headache Association
Homeopathic Treatment in patients with migraine (2006)
8.International Journal of Clinical Pharmacology and Therapeutics
Homoeopathic treatment of otitis media (1997) FULL TEXT // n=131, duration of pain of 2 days in homeopathy-group (n=103) & 3 days in conventional (antibiotic, antipyretic, secretolytics) group (n=28). 70.7 % & 56.5% of children receiving homeopathy & conventional respectively did not have another ear infection the next year
9.The Clinical Journal of Pain
Homeopathic Treatment of chronic low back pain (2009) n=129, t=2 years, quality of life improved
10. Oncology Reports
Lung (4 cases) and oesophageal Cancer patients treated with the Banerji protocols: A Best Case Series Program of the National Cancer Institute USA (2008) FULL TEXT // Concluded that there was sufficient evidence of efficacy to support further research into the Banerji protocol
11. Indian Journal of Ophthalmology
Role of homoeopathy in ophthalmological conditions (1982) FULL TEXT
12. Geriatrics
Homeopathic Treatment of Elderly Patients (2010) FULL TEXT //severity of complaints (hypertension and sleep disturbances) of 83 patients over 2 years time decrease significantly
13. Experimental Biology and Medicine
in vitro studies shows anti-cancer activity of Gelsimium 2-4c (2008) FULL TEXT // https://docs.google.com/document/d/1zKIz3A9nIfsW0xghfZ9Myd9Xk_YN_PBPTwe6UozgreU/edit
14. Canadian Journal of Physiology and Pharmacology
Gripp-Heel (Aconitum 4X, Bryonia 3X, Eupatorium 2X, Lachesis 11X, Phosphorous 4X) for respiratory viral infections (2007) FULL TEXT // in vitro
15. The Pediatric Infectious Disease Journal
Individualised Homeopathic treatment of otitis media (2001) //otitis media: inflammation of middle ear, n= 75, 8 different remedies in C30 potency; 4 most commonly used (88%) were Pulsatilla nigrans, Chamomilla, sulphur, Calcarea carbonica; 3-5 pellets 3 times daily, significant decrease in symptoms at 24 and 64 hrs after treatment in favour of homeopathy (P<0.05) compared to placebo, OR=1.84, Jadad score=5
16. Journal of the European Academy of Dermatology and Venereology
Homeopathic treatment of patients with psoriasis (2009) http://www.ncbi.nlm.nih.gov/pubmed/19192019
17.Wiener medizinische Wochenschrift
Homeopathy in emergency medicine (2005) FULL TEXT // critically ill patients in ICU
18. Ultrastructural Pathology
Canova differentiates monocytes in absence of cytokines(2008) FULL TEXT // combination remedy, in vitro
19. Genetics and Molecular Research
Canova for cancer treatment(2003) FULL TEXT
20. Advanced Therapies
Arnica montana gel in osteoarthritis of the knee (2002)// n=79,significant reduction in pain and stiffness, and a significant improvement in the functional ability of the knee.
21. Arzneimittel-Forschung
Antioxidative, antiproliferative and biochemical effects of Hepeel (Carduus marianus, Cinchona, Lycopodium, Nux moschata, Colocynthis D6, Veratrum album D6, Chelidonium, Phosphorus D6) in HepG2 cells (2003) //in vitro, combination, as well as the effects individually
22. The Lancet
Prophylactic powers of Belladonna against Scarlet Fever (1829)// The proper use of belladonna has, in most cases, prevented infection. Numerous observations have shown that, by the general use of belladonna, epidemics of scarlet fever have actually been arrested. In those few instances where the use of belladonna was insufficient to prevent infection, the disease has been invariably slight.
23. STP Pharma Sciences
Anti-inflammatory action of combination of Urtica Urens 4c and Apis 4c AND Belladonna 4c and Pulsatilla 4c (1999) // combination remedy
24.Dermatology
Individualised Homoeopathic versus conventional therapy for atopic eczema in children (2009) //n= 135, t=1 year, corticosteroid and anti-histamine, Jadad score=1
25. Cases Journal
Exfoliative cheilitis (inflammation of lips) treated with Calendula (2009) FULL TEXT
26. Palliative Medicine
Homeopathic approach to symptom control in the cancer patient (2002)
27.Ear, Nose and Throat disorders
Homeopathic treatment of patients with chronic sinusitis (2009) FULL TEXT
28.Bulletin of Experimental Biology and Medicine
Potentised Ethanol for alcohol withdrawl and Potentised morphine for morphine addiction (2003) http://www.ncbi.nlm.nih.gov/pubmed/12949688
29. Journal of Musculoskeletal Research
Traumeel vs NSAID for inflammation of the epicondyle (2004) FULL TEXT // Traumeel superior to NSAID on variable pain at rest (p<0.01), joint mobility (p<0.01) http://www.heel.com/upload/attachment_62_8028.pdf
HOMEOPATHY JOURNALS
1.Homoeopathic Links
Usefulness of the Homeopathic Medicines in Furunculosis (2010) // Hepar sulphuris, Antimonium crudum, Sulphur and Calcarea carbonica for boils,p=0.0001 in the mean total furunculosis symptom score developed by the CCRH
Efficacy of homeopathic drugs in dermatitis of atopic diathesis (2003) // n=31 people suffering from atopic skin and respiratory symptoms with individualised homeopathic therapy (Arsenicum album, Merc solubilis, Hepar sulph, Arsenicum iod, Antimony tart, Pulsatilla and Calc carb)over a period of 5 years. During a 6 month assessment period following this treatment, the authors determined that 41% of the group with skin and respiratory symptoms achieved not less than a 76% improvement in symptoms.
2. The British Homoeopathic Journal
Potentised Carboneum sulphuratum and Tabacum in Cuban epidemic neuropathy (2001) //
Individualised Homeopathic treatment in women with premenstrual syndrome (2001) FULL TEXT // n=19, 90% of patients who had received homeopathic treatment (200c potency) experienced more than 30% improvement (P=0.048). Only 37.5 % of patients who received placebo experienced a similar improvement, OR=5.5
Treatment for hyperactive children: homeopathy and methylphenidate (ritalin) compared (2001) // ADHD, individualised LM potency, n=114 (3-17 years), t=3.5 months, 86 (75%) responded to homeopathy, 22% responded to methylphenidate, 3% to none of them
Quality of life in patients with headache, receiving homeopathic treatment (2001) FULL TEXT // statistically significant results in favour of homeopathy, n=53, t=4-6 weeks, >60% improvement in 4 weeks
Homeopathic treatment of patients with persistent mild traumatic brain injury (MTBI) (2000) FULL TEXT // 50 people with persistent MTBI were treated either with their constitutional homeopathic remedy or placebo. The homeopathic treatment provided superior results to those from the placebo control
Quadruple nosode (Bacillinum, Influenzinu, Pneumococcus and Streptococcus) as a preventive for respiratory infections (1964) // combination remedy
Poliomyelitis and prophylaxis (1950)// In 1950 during an epidemic of poliomyelitis, Dr Taylor Smith of Johannesburg, South Africa protected 82 people with homoeopathic Lathyrus sativus. Of the 82 so immunised, 12 came into direct contact with disease. None were infected.
Evaluation of 2LHERP in preventing recurrences of genital herpes (2000) // nosode, combination remedy 2LHERP=homeopathic RNA+homeopathic viral DNA
Calcarea Fluorata for Cervical Spondylitis (1996) // n=154, t=1 year, clinical improvement in 60.38%,40% in those given medicine other than calc fluor
Sulphur for treatment of Alcohol Withdrawl (1993) //n=30, t=3 months, alcohol withdrawal and delirium, Poland
Staphylococcus 12c decreases immune complexes, increases CD4 lymphocytes in HIV patients (2000)// n=16, case series of 12 infected and 4 healthy persons
Homeopathy in acute otitis media(2001) FULL TEXT // n=230, t=12 hours, 72% of those using homeopathy had significant relief. Resolution rates were 2.4 times faster than in placebo controls. Compared to conventional treatment the homeopathic approach was 14% cheaper
Applicability of Caulophyllum 7C during labour(1993) // n=22, reduces duration of labour by 90 minutes
Individualised Homeopathy in treatment of Fibroid in Uterus (1992) // n=84, t=1-3 years, pain improved in 79% of subjects, abnormal bleeding in 75 % subjects, reduction fibroid volume in majority of cases http://www.homeopathyjournal.net/article/S0007-0785%2805%2980172-3/abstract
3. International Journal of High Dilution Research
Effect of homeopathic medication on the cognitive and motor performance of autistic children (2008) FULL TEXT // autism
Homeopathic treatment of coronary artery disease (2009) FULL TEXT
Homeopathic treatment of Dengue (2008) FULL TEXT
Tongue Analysis (2009) FULL TEXT
Carbon Remedies (2009) FULL TEXT
Nephrotic Syndrome in adults (2009) FULL TEXT //tuberculinum, apis, arsenicum album, etc
Usefulness of 13 homeopathic medicines in the management of acute rhinitis(2010) FULLTEXT // Nux-Vomica, Merc, Belladonna,pre- and post-score assessment as per acute rhinitis symptom score developed by CCRH showed statistically significant improvement, p<0.05
4.Homeopathy
Individualised Homeopathy for treatment of symptoms of oestrogen withdrawal in breast cancer patients (2003) // n=45, Primary symptoms such as hot flushes,Primary symptoms changed from 7.8 to 5.4, and from 7.2 to 4.1 (p<0.001), super-avogardo dilution
An observational study of patients receiving homeopathic treatment (2004) FULL TEXT //improved physical condition & high satisfaction in 782 patients, t= 9 years 2 months, costs less, individualised treatment, allopathy drug discontinued
Effectiveness of homeopathic care in Norway (2005) FULL TEXT // 70% reported improvement in 6 months, Patients using conventional medications reduced them from 39% to 16%
Homeopathy for hyper-sensitivity (2006) FULL TEXT // n=88,24% of 34 treated conventionally experienced an improvement in their condition while 57% of 54 treated with homeopathy experienced similar relief.
Treating hot flushes in menopausal women with homeopathic treatment (2008) FULL TEXT //n=438, Significant reduction in the frequency of hot flushes and significant reduction in daily discomfort.
Homeopathic treatment of allergic rhinitis (2009) FULL TEXT // n=46
Cost-benefit evaluation of homeopathic versus conventional therapy in respiratory diseases (2009) FULL TEXT // treatment by homeopathy costs 50% less, individualised homeopathy
Homeopathic therapy for male infertility (2002) //n=45,t=10.3 months, A total of 26 homoeopathic medicines in LM 18 potency were prescribed, the most common ones were (in order of the number of prescriptions): Natrum muriaticum, Lycopodium, Calcarea carbonicum, Pulsatilla, Phosphous, Silicea, and Thuja. Sperm count and sperm motility were improved by homeopathy and the improvement was comparable with conventional treatment. p=0.011 for sperm density and p=o,o45 for motility. A total of 8 pregnancies occurred in 7 couples, with one having twins
Individualised Homeopathy as an adjunct to usual care for fibromyalgia (2009) //n=47, p<0.01 on Fibromyalgia impact Questionnaire score in favour of homeopathy (7.62 vs 3.63), randomized, OTP controlled, Jadad score=2
Homeopathy in respiratory allergies (2006) FULL TEXT // n=147
Homeopathy for the treatment of menstrual irregularities: a case series (2009)
Homeopathic treatment of radiation-induced itching in breast cancer patients (2004) //21 out of 25 benefitted from individualised homeopathy
Canova in vitro (2009) FULL TEXT
Homeopathy for arthritis (2008)// n=47
Homeopathic treatment of intractable atopic dermatitis (2003) // n=17
Application of 200C potency of bacteria for Leptospirosis epidemic control (2010) FULL TEXT // Conducted by the Finlay Institute, a vaccines producer in Cuba gave 2.308562 million (70% of the target population above the age of 1 year) people in Cuba given two doses (1 dose=5 drops) of 200C potency of Leptospirosis bacteria, each (7-9 days apart) for protection against Leptospirosis (fever+jaundice+ inflammation in kidney+enlargement of spleen) with only 10 reported cases. Dramatic decrease in morbidity within two weeks and zero morbidity of hospitalised patients, non-treated area saw an inrease in number of cases from 309 cases in 2007 to 376 in 2008 representing a 21% increase. cost of homeopathic immunization =1/15th of conmed vaccine. https://drive.google.com/file/d/0B0b69JqzK_44ODcxYWY0MTAtOGQ1NC00MmUzLWI4NDQtZThjZWUyY2E1ZWRk/edit
5. Journal of the American Institute of Homeopathy
Poliomyelitis immunization (1961) // In 1956,Dr H.W. Eisfelder immunized over 6,000 children with this Lathyrus sativus. There were no side effects and no cases of polio reported in the group
6. American Journal of Homoeopathic Medicine
Acute Diarrhoeal Diseases in Children, 2009, 102 (3): 122-129 //n=327, The difference in the mean number of stools and diarrhoea index score (before and after treatment) developed by the CCRH was found to be statistically significant (p=0.0001). Podophyllum, Chamomilla, Aethusa cynapium, Calcarea Carbonica and Mercurius solubilis were found to be most useful, individualised homeopathy
Hahnemann’s Contribution
7. Zeitschrift für Praktischen Medizin
A case of rapidly cured colicodynia, Vol. 3. Part. 1, p. 138-147, 1797
Cure and prevention of scarlet fever, 1801
8.Reichs Anzeiger
On a proposed remedy for hydrophobia, No. 7, 49, 71, 1803.
9.Allgemeine Reichsanzeiger
Treatment of typhus & fever at present prevailing, No. 6, Jan. 1814 // Bryonia and Rhustox.
Treatment of burns, No. 156, 1816
Treatment of purpura miliaris, No. 26, 1821 // blockage of sweat glands
10.Archiv für die homöopathische Heilkunst
Cure and prevention of Asiatic cholera, Vol. 11, part 1, 1831
11.The British Journal of Homoeopathy
Treatment of chronic local disease and of phthisis. Vol. 11, 1853 // Tuberculosis
CAM JOURNALS
1.Complementary Therapies in Medicine
Traumeel for trauma and acute musculo-skeletal injuries (2008)
Homoeopathic versus conventional treatment of children with eczema (2008) // n=118, t=1 year,those children who were treated homeopathically had a greater level of recovery from symptoms than those treated with corticosteroid and anti-histamine, p<0.001, cohort study, Jadad score=1
Homoeopathic Vs conventional treatment strategies in patients with chronic disorders (2005) FULL TEXT // n=493,t= 1 year, chronic disorders such as headache, lower back pain, insomnia, depression, bronchial asthma, atopic dermatitis and allergic rhinitis
2. Forschende Komplementärmedizin und Klassische Naturheilkunde
Treatment of rhinitis & sinus with Euphorbium compositum nasal drops (2005) n=739
3. Evidence-based Complementary and Alternative Medicine
NervoHeel N for Nervous Disorders (2007) FULL TEXT //other than-placebo control: Lorazepam
Can Homeopathy Bring Additional Benefits to Thalassemic Patients: Encouraging Results (2010) FULL TEXT // n=38,significant decrease in the serum ferritin and increase in fetal haemoglobin levels in subjects treated with homeopathic remedies in combination with Hydroxyurea. In the 30 patients having enlarged spleen, there was a reduction in size of spleen. There was an increase in the interval period of blood transfusion requirement (ranging between 25 and 75%) in the combined treatment group.
Asenicum Album 30c to combat arsenic poisoning (2005) FULL TEXT // placebo-controlled,n=53, Arsenic concentration in the urine of verum group was significantly lower on 6/11 days
4. The Journal of Alternative & Complementary Medicine
Homeopathy versus conventional treatment in respiratory tract and ear complaints (2001) FULL TEXT // other-than-placebo controlled trial, homeopathic medicine in 30c potency, response rate of 82.6% in homeopathy group compared to 67.3% in conventional group
Homeopathic Treatment for Chronic Disease (2005) FULL TEXT // 70.7% of 6544 patients over 6- year period reported improvement, 50% had major improvement in inflammatory bowel disease, irritable bowel syndrome, menopausal problems and migraines. Children had improvements in eczema and asthma.
Tumor (blood cancer) Therapy with Amanita phalloides (2010) FULL TEXT
Immune-modulatory effects of Phase 6 and Flu Terminator (2007)// elicts human immune response in-vitro, combination remedies
5.Complementary & Alternative Medicine
Patient satisfaction & side effects: comparing homeopathy & conventional medicine (2008) FULL TEXT // swiss govt. report, higher patient satisfaction & 3 times fewer side-effects in homeopathy,21% of those treated with homeopathy reported “complete resolution” of the complaint versus 28% of those on conventional therapy and 53% reported “complete satisfaction” with homeopathic treatment versus 40% of those given conventional therapy. http://www.biomedcentral.com/1472-6882/8/52
Homeopathic & conventional treatment for acute respiratory & ear complaints (2007) FULL TEXT // n=1577 from 57 clinics in 8 countries, t-14 days. The onset of improvement within the first 7 days after treatment was significantly faster in those with homeopathic treatment, both in children and adults.
6. Alternative Therapies in Health and Medicine
Cost saving by Homeopathy in atopic and allergic disorders (2002) // n=48, 56%of patients reduced their use of conventional medication following the homeopathic intervention,medication expense reduced by an average of 60%, with an average savings of $24 per patient in the 3-month period following the homeopathic intervention.
Homeopathic treatment of depression and anxiety(1997) // n= 12, t=7 to 80 weeks, 58% of patients responded to homeopathy for anxiety and phobia
7.Complementary Therapies in Clinical Practice
Homoeopathic treatment of upper respiratory tract infections in children (2010)
8.Forschende Komplementarmedizin
Effect of Coffea Cruda on mood, anger and depression in insomnia patients (2010) //n=59, t=1month
F9. REVIEW ARTICLES (other than systematic reviews)
1. Alternative Medicine Review
A review of homeopathic research in treatment of respiratory allergies (2010) FULL TEXT
2. International Journal of High Dilution Research
Flu pandemics: homeopathic prophylaxis and definition of the epidemic genius (2009) FULL TEXT
20 years of experience with LM potencies (2009) FULL TEXT
Homeopathy: a preventive approach to medicine (2009) FULL TEXT
Repertory based on Baye’s theorm (2010) FULL TEXT
Scientific framework of Homeopathy: Evidence-based Homeopathy (2008) FULL TEXT
3.Evidence-based Complimentary & Alternative Medicine
Immunology and Homeopathy -1 (2005) FULL TEXT
Immunolgy and Homeopathy-2 (2006) FULL TEXT
Immunolgy and Homeopathy-5 (2006) FULL TEXT
Entanglement Theory (2007) FULL TEXT
4. Journal of Clinical Epidemiology
Homeopathy had a significant effect beyond placebo (2008) FULL TEXT //(odds ratio= 0.76) with p=0.039 at 95% CI, meta-analysis
5. Homeopathy
Canova in vitro (2009) FULL TEXT
6.Forschende Komplementarmedizin
Real-world Effectiveness, Safety and Cost-Effectiveness of Homeopathy in General Practice(2006) FULL TEXT // Swiss govt commissioned Health Technology Assessment Committee comprising of 10 scientists including 3 homeopaths concluded after 7 years of research: 20 out of 22 systematic reviews having a trend in favour of homeopathy, re-evaluated shang study taking into account external and internal validity and found a truly remarkable result in favour of homeopathy.
J. ANIMAL STUDIES
http://www.carstens-stiftung.de/clinresvet/suche.php // Database of 304 papers. Click “Retreive long version”
Click to access Animal%20Studies%20by%20Date%20of%20Publication.pdf
http://hpathy.com/scientific-research/research-in-homoeopathy/3
http://avilian.co.uk/2008/08/scientific-research-and-homeopathy-animal-studies
L1. SIGNIFICANT YEARS OF RESEARCH
1823: World’s first homeopathy Journal (German): Dr. Johann Ernst Stapf’sArchive for the Homoeopathic Medicine
1835: World’s first Double-Blind Randomised Placebo Controlled Trial was conducted by a homeopath physician Johann Jacob Reuter, The Nuremberg salt test
1860: World’s first homeopathy Journal (English):The North American Journal of Homeopathy
1988: The Memory of Unique Water Structures (Dr. Jacques Beneviste)
1991: Potentisation creates molecular clusters in water
1995: Homeopathy is nanopharmacology (Paolo Bellavite, Andread Signorini)
1997: Homeopathic medicines have the capacity to interact with the genetic blueprint (Anisur Rahman Khuda-Bukhsh)
1999: Potentisation alters the properties of Water (Elia V, Niccoli M)
2001: Alcohol forms clusters with water (Wisniewski)
2005: Potentisation alters the structure of water (Dr. Rustom Roy)
2007: Succussion creates nano-bubbles and Transient Localised regions
2008: homeopathic medicines have stable and unique molecular structure with recognizable properties (Dr. Rustom Roy)
2009: Potentisation creates specific nano-structures (Dr. Luc Montagnier, Nobel Laureate)
2010: Homeopathic medicine upto 200c retains nano-grams of fine nano-particles of the original starting material (Indian Institute of Technology, Bombay)
L2. RESEARCH BOOKS
1.The Trials of Homeopathy. Michael Emmans Dean. KVC Verlag. 2004 // Trials from 1821-1998,5 prospective trials and 205 controled trials, conclusion: “homeopathy appears mostly as safe as reputed”, “homeopathy does appear to be capable of influencing global outcomes such as well being and co-morbidity”, “economic benefits are noticeable”
2.The Emerging Science of Homeopathy.Complexity, Biodynamics and Nanopharmacology. Paolo Bellavite, Andread Signorini. North Atlantic Books. Berkeley, California. 1995. ISBN 1-55643-384- 0. http://bit.ly/d30Tll
M1. POTENCY SELECTION
Golden ratio/Fibonacci scale of remedies
M2. DISCUSSION FORUMS
Rational Skepticism-1 // TMB
Rational Skepticism-2 // TMB
Phoenix Rising // Mark
Peer-review Vs public scrutiny
SECTION-B
A. GENETIC RESEARCH
Anisur Rahman Khuda-Bukhsh in his paper “Potentized homeopathic drugs act through regulation of gene expression: a hypothesis to explain their mechanism and pathways of action in vivo” Com Ther Med. 1997: 5; 43. proposed that homeopathic substances have the capacity to interact with the genetic blueprint and deliver their benefits by increasing the expression of genes that synthesise health promoting proteins i.e. homeopathic medicines activate genes i.e.genes can be turned on and off by use of homeopathic remedies
Dynamized Preparations in cell Culture (2009) FULL TEXT // Carcinosinum200C,Conium,Lycopodiumactivates beneficial gene p53 which provides defense against tumour/cancer
Nux vomica & Calendula have significant effect on gene expression (2010) FULL TEXT
Evaluation of 2LHERP in preventing recurrences of genital herpes (2000) //nosodes, combination remedy, 2LHERP=homeopathic RNA+homeopathic viral DNA
overview:http://www.complementary-medicine.com/NewHomeopathy1.htm
http://www.complementary-medicine.com/NewHomeopathy2.htm
B1. IDENTIFICATION OF HOMEOPATHIC MEDICINES (4techniques)
A.Spectroscopy: It is the study of interaction between matter and radiated energy i.e. how a substance absorbs, emits or scatters electromagnetic radiation
1.Raman Laser Spectroscopy (1976)
In 1976, Boiron and Vinh used Raman Laser Spectroscopy, showing that for the 1C potency of Kali bichromicum the spectrum of alcohol disap-pears completely, while that for potassium bichromate appears. In Kali bich 1C the ratio of the number of potassium bichromate molecules is 1 to 500. In such a case the light meets 500 more alcohol molecules as those of bichromate, yet the alcohol spectrum does not appear.
2. New Magnetic Resonance method by K. Lenger (2006)
Homeopathic Potencies Identified By a New Magnetic Resonance Method published in journal ‘Subtle Energies and Energy Medicine’
Delayed luminescence of high homeopathic potencies on sugar globuli (2008)
3. Ultra-Violet–Visible spectroscopy (2007)
The defining role of structure including epitaxy in the plausibility of homeopathy (2007) FULL TEXT // distinguishes Nux vomica and Natrum muriaticum from one another and within a given medicine, the 6c, 12c, and 30c potencies, distinguishes Natrum Mur, Puls and lachesis at 30c potency
4. Nuclear Magnetic Resonance (NMR) spectroscopy (2008)
The first NMR spectroscopy in homeopathy was by Boericke GW, Smith RB. Modern aspects of homeopathic research.Journal of the American Institute of Homeopathy,1965; 58: 158-167; 1966; 59: 263-272.
NMR spectroscopy on Kalium Bichromium (2008) FULL TEXT // 3C differs from 4C
High dilutions of histamine distinguishable using NMR (2009)
discussion
http://hpathy.com/scientific-research/lionel-milgrom
http://hpathy.com/homeopathyforums/forum_posts.asp?TID=8879
http://forums.hpathy.com/forum_posts.asp?TID=9047
http://www.hpathy.com/homeopathyforums/forum_posts.asp?TID=6908&PN=4
5. Electromagnetic Signatures (2009)
Nanostructures in highly diluted biological samples of bacteria and virus DNA sequence produces electro-magnetic signals (2009) FULL TEXT
Low temperature thermo-luminescence of ultra-high dilutions of lithium chloride & sodium chloride (2003) FULL TEXT
C. Dielectric Dispersion (2010)
D. Physiological variability in human body (G.D. Jindal et. al., 2004): homeopathic medicines produce change in body temperature by its action on hypothalamus
Software for measuring physiological variability (2008)
discussion
http://homeoresearch.blogspot.com // check research work in left pane
http://h-wave.blogspot.com/2007_12_01_archive.html
http://www.homeopathyworldcommunity.com/profiles/blogs/bhabha-atomic-research-centre
B2. TO DISTINGUISH HOMEOPATHIC MEDICINE FROM THE SOLVENT/CONTROL(5 techniques)
1. Bio-Electro-graphy: Dynamic Electrophotonic Capture: Gas Discharge Visualisation (2003)
Gas Discharge Visualization Evaluation of Ultramolecular Doses of Homeopathic Medicines (2003)
2. Fourier Transform Infra Red spectroscopy (2005)
Variation in Fourier transform infrared spectra of homeopathic potencies (2005) FULL TEXT
3. High Voltage Plasma (2008)
Distinguishing Natrum Mur 30 from water by High voltage plasma (2008) // electrical impedance of Natrum Mur 30 c differ from water
4. Transmission Electron Microscopy (2010)
Presence of nanoparticles in homeopathic medicines as detected by TEM while there won’t be any nanoparticles detected in solvent/control because it is a placebo
5. Ultra-Violet Spectroscopy (2011)
Cuprum Sulphuricum 11-30c differs from placebo (2011)
D. COMPARISON WITH CONMED AND PLACEBO
By the end of year 2008, there have been 14 RCT comparing homeopathy to ConMed [ref]
The distribution of studies in a form of a table comparing homeopathy with Con-Med and placebo is shown at https://drnancymalik.wordpress.com/article/research-database-in-homeopathy-2/
D1. HOMEOPATHY SUPERIOR TO CONMED
DBRCT have shown superiority of homeopathy over allopathy in treatment of otitis media, depression, low back pain, upper respiratory tract infection, trauma and musco-skeletal injuries, so can be used as first line of treatment
1.Explore: The Journal of Science and Healing
Viburcol (Chamomilla, Belladonna, Calcarea carbonica, Dulcamara, Plantago major, and Pulsatilla) for treatment of febrile infctions in children(2005) //febrile symptoms such as fever, cramps, disturbed sleep, difficulty eating or drinking, crying=198 in 38 Belgian Clinics, Viburcol as effective as acetaminophen but better tolerable
Traumeel S ointment for tendon injuries (2005) // Traumeel superior to diclofenac gel
2.Scientific World Journal
Avena Sativa 2X, Passiflora Incarnata 2X, Zincum Valerianicum 4X, Coffea Cruda 12X for treatment of Insomnia (2008) // Neurexan superior to valerian
3.International Journal of Clinical Practice
Gripp-Heel (Aconitum napellus 4X, Bryonia alba 4X, Eupatorium perfoliatum 3X, Lachesis, Phosphorous) for viral infections-(2004) FULL TEXT //combination remedy, n=485, 78.1% of people found it effective compared to 52.2% of those using conventional medicine
4. American Journal of Pain Management
Osteo-arthritic Pain: A Comparison of Homeopathy and Paracetamol (1998) // 55% achieved pain relief from homeopathy as compared to 38% from acetaminophen
5.Homeopathy
Homeopathy as an adjunct to usual care for fibromyalgia (2009) FULL TEXT
An observational study of patients receiving homeopathic treatment (2004) FULL TEXT //improved physical condition & high satisfaction, costs less, allopathy drug discontinued
Homeopathy for hyper-sensitivity (2006)
Homeopathic & antibiotic treatment strategies in recurrent acute rhinopharyngitis (2005) // Inflammation of the mucous membranes of nose & throat, homeopathy superior to anti-biotic
Homeopathic and conventional therapies in patients with type-2 diabetic polyneuropathy(2009) //n-61, t= 1 year, p=0.016
6.British Homoeopathic Journal
Efficacy and safety of a homeopathic gel Spiroflor SRL in the treatment of acute low back pain (2001) FULL TEXT // SRL (Symphytum, RhusTox, Ledum Pal) is equally effective as Cremor Capsici Compositus FNA but has better safety profile, Double-blind Randomised Trial with n=21
7.Complementary & Alternative Medicine
Patient satisfaction & side effects: comparing homeopathy & conventional medicine (2008) FULL TEXT // higher patient satisfaction & 3 times fewer side-effects in homeopathy
8.International Journal of Clinical Pharmacology and Therapeutics
Homoeopathic treatment of otitis media (1997) // duration of pain of 2 days in homeopathy-group & 3 days in conventional group. 70.7 % & 56.5% of children receiving homeopathy & conventional respectively did not have another ear infection the next year
9. Evidence-based Complementary & Alternative Medicine
Homeopathic LM potencies Vs Fluoxetine for Depression (2009) FULL TEXT //Homeopathy not inferior to fluoxetine (Prozac) but had a better safety profile,Higher percentage of patients treated with fluoxetine reported troublesome side effects and there was a trend toward greater treatment interruption for adverse effects in the fluoxetine group compared to homeopathy, Double-blind Randomised Trial with n=91
10.Complementary Therapies in Medicine
Homeopathy for the prevention of upper respiratory tract infections (2005) Randomised Controlled Trial with n=69. The difference in the median number of days with URTI symptoms was statistically significant with 8 days in the homeopathic group and 13 days in the control group (p = 0.006)
Traumeel for trauma and acute musculo-skeletal injuries (2008)
11.Journal of Clinical Oncology
Phase 3 RCT of Calendula compared with trolamine for prevention of dermatitis during radiotherapy for breast cancer(2009) //n=254, p<0.001, reduction in high energy radition-induced pain, superior to trolamine
D2. HOMEOPATHY COST-EFFECTIVE THAN CONMED
Between 2001-2010, 24 economic evaluations including 13 full economic evaluations done, ref: Hermann P, Poindexter B, Witt CM, Eisenberg D. BMJ Open 2012
The cost of homeopathic medicines are much less than conmed because they are generic, non-patented and non-patentable.
Cost-benefit evaluation of homeopathic versus conventional therapy in respiratory diseases (2009) FULL TEXT // treatment by homeopathy costs 50% less
Homeopathy in acute otitis media (2001) FULL TEXT // n=230, After 12 hours, 72% of those using homoeopathy experienced significant relief of symptoms, which was 2.4 times faster than the response to placebo.Compared to conventional treatment the homeopathic approach was 14% cheaper
Arnica montana 4X for Healing of Wounds After Hallux Valgus Surgery Compared to Diclofenac 50 mg(2008) // n=88, t= 4 days, arnica provided same level of wound irritation reduction but 60% cost-effective than diclofenac
Homeopathic and conventional therapies in patients with type-2 diabetic polyneuropathy(2009) //n-61, t= 1 year, p=0.016
D3. HOMEOPATHY EQUALS CONMED
1.Archives of Otolaryngology- head & Neck Surgery
Homeopathic Vs conventional treatment of vertigo (1998) FULL TEXT //Double Blind Randomised Controlled trial with n=119, Statistical Significant results with homeopathy as well as betahistine
2.The European Journal of Heart Failure
Efficacy of homeopathic Crataegus & Spigelia for mild cardiac insufficiency (2003) FULL TEXT // Crataegus & Spigelia Vs ACE inhibitors/Diuretics
3. Explore: The Journal of Science and Healing
Asclepias vincetoxicum & Sulphur for treatment of upper respiratory infections associated with common cold (2006) // homeopathy Vs anti-histamine and anti-inflammatory drugs
4. Biologische Medizin
Vertigoheel Vs Dimenhydrinate for vertigo(2001) FULL TEXT // 88% patient improved compared to 87 % in conventional group
Viburcol for infections due to fever (2002) FULL TEXT // equals paracetamol
5. Der Allgemeinarzt
Zeel (Rhus Tox, Dulcamara, Sanguinara, Arnica) for osteo-arthritis (2003) FULL TEXT // equals COX 2 inhibitors
6. Homeopathy
Placebo effect size same in conventional & homeopathic medicine (2010) FULL TEXT
7. Complementary & Alternative Medicine
Homeopathic & conventional treatment for acute respiratory & ear complaints (2007) FULL TEXT // homeopathy Vs anti-biotics & analgesics for respiratory & ear complaints
8. Forschende Komplementärmedizin und Klassische Naturheilkunde
Comparing Luffa compositum-Heel nasal spray with cromolyn sodium spray in the treatment of allergic rhinitis (1999) FULL TEXT Double-blind Randomised trial with n=146,Homeopathic Nasal Spray containing Luffa, Galphimia, Histamine and Sulphur is as efficient and well tolerable as conventional therapy as Cromolyn Sodium
Treatment of rhinitis & sinus with Euphorbium compositum nasal drops (2005) // Homeopathy Vs xylometazoline, n=379
9. Evidence-based Complementary and Alternative Medicine
NervoHeel N for Nervous Disorders (2007) FULL TEXT
10.Arzneimittel-Forschung
Comparison of acetylsalicylic acid with Eupatorium perfoliatum 2X in treatment of common cold (1981) //RCT
11.Dermatology
Homoeopathic versus conventional therapy for atopic eczema in children(2009)
D4. HOMEOPATHY SUPERIOR TO PLACEBO
1. Journal of Clinical Epidemiology
Conclusions on the effectiveness of homeopathy depend on the set of analyzed trials (2008)// FULL TEXT homeopathy had a significant effect beyond placebo (odds ratio= 0.76) with p=0.039 at 95% CI
2. Forschende Komplementarmedizin
Homeopathic patho-genetic trials produce specific symptoms different from placebo (2009) FULL TEXT // homeopathy differs from placebo, n=25
3.Homeopathy
Double-blind Placebo-controlled homeopathic patho-genetic trials (2006) FULL TEXT
The 2005 meta-analysis of homeopathy: the importance of post-publication data (2008) FULL TEXT //Quality of homeopathic Trials is better than of conventional trials for all trials (p=0.03) as well as for smaller trials (p=0.003)
4. British Homoeopathic Journal
Homeopathic treatment in women with premenstrual syndrome (2001) FULL TEXT // 90% of patients who had received homeopathic treatment experienced more than 30% improvement (P=0.048). Only 37.5 % of patients who received placebo experienced a similar improvement, n=20
5.Complementary Therapies in Medicine
Homeopathy, sensation of well-being and CD4-levels (1998) FULL TEXT // individualised homeopathy improves sensation of well-being, provided evidence of ultra-high dilutions and may affect CD4 levels, n=36
Arnica for inflammation after knee surgery (2006) //Double-Blind Randomised Placebo Controlled trial with n=226
6. The Journal of Alternative and Complementary Medicine
Variation in Fourier transform infrared spectra of homeopathic potencies (2005) FULL TEXT // FTIR spectra of Nux Vomica 30c, Lycopodium 30c, Santonin 30c, Cina 30c distinguishes from solvent, sugar globule soaked in homeopathic medicine retains its specific spectral absorption propoerties
Gas Discharge Visualization Evaluation of Ultramolecular Doses of Homeopathic Medicines (2003) // distinguishing homeopathic medicine from solvent using Bio-Electro-graphy: Dynamic Electrophotonic Capture
7. British medical Journal
Clinical Trials of Homeopathy (1991) FULL TEXT // 77% of 105 studies show positive result of homeopathy
8.Journal of Psychosomatic Research
Efficacy of individualised homeopathic treatment for chronic fatigue syndrome (2004) Triple-Blind Study with n=92 Weak but equivocal evidence that the effects of homeopathic medicine are superior to placebo
9. Journal of Clinical Gastro-enterology
homeopathy for post-operative ileus (1997) // E. Ernst, 6 trials, 776 patients (meta-analysis) Statistically significant (p < 0.05) weighted mean difference in favor of homeopathy (compared to placebo)
10. Wiener Medizinische Wochenschrift
homeopathic Galphimia glauca for hay fever (1997) // meta-analysis of 11 controlled trials: Significant superiority of Galphimia glauca over placebo is demonstrated
E. OUTCOME STUDIES
E1. HOMEOPATHY IMPROVING QUALITY OF LIFE
Homeopathic medical practice (2005) FULL TEXT // (Chronic) Disease severity and quality of life demonstrated marked and sustained improvements following homeopathic treatment in 3981 patients for 2 years
Disease severity decreases & QoL of life increases following homeopathy treatment (2008) FULL TEXT
http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/286/354 (2008)
Treatment of allergic rhinitis with homeopathy (2005)
Homeopathic treatment of allergic rhinitis (2009)
Homeopathic Treatment of chronic low back pain (2009)
Scientific framework of evidence-based homeopathy (2008) FULL TEXT // page 4-5
Homeopathic and conventional therapies in patients with type-2 diabetic polyneuropathy(2009) //n-61, t= 1 year, p=0.016
Improved Clinical Status in Fibromyalgia patients treated with homeopathic remediesVs Placebo (2004) FULL TEXT // significantly greater improvements in tender point count and tender point pain, quality of life, global health and a trend toward less depression compared with those on placebo.
Homeopathic & antibiotic treatment strategies in recurrent acute rhinopharyngitis(2005) //In 499 patients homeopathy yielded significantly better results than antibiotics in terms of effectiveness, number of complications and quality of life
Quality of life in patients with headache, receiving homeopathic treatment(2001) FULL TEXT // statistically significant results in favour of homeopathy
E2. SAFETY PROFILE OF HOMEOPATHIC MEDICINES
1.Forschende Komplementarmedizin
Effectiveness, Safety and Cost-Effectiveness of Homeopathy in General Practice (2006) FULL TEXT
2.British Homoeopathic Journal
Efficacy and safety of a homeopathic gel Spiroflor SRL in the treatment of acute low back pain (2001) FULL TEXT // SRL (Symphytum, RhusTox, Ledum Pal) is equally effective as Cremor Capsici Compositus FNA but has better safety profile, Double-blind Randomised Trial with n=21
3. Evidence-based Complimentary & Alternative Medicine
Homeopathic LM potencies Vs Fluoxetine for Depression (2009) FULL TEXT //Homeopathy not inferior to fluoxetine (Prozac) but had a better safety profile. Higher percentage of patients treated with fluoxetine reported troublesome side effects and there was a trend toward greater treatment interruption for adverse effects in the fluoxetine group compared to homeopathy, Double-blind Randomised Trial with n=91
UPDATE: UPTO THE END OF 2011
164 peer-reviewed papers published between 1950-2011 (inclusive) on RCT in 89 medical conditions
(1) Out of 164, 137 are placebo-controlled & 27 other-than-placebo controlled studies
(2) Out of 164, 71 (43%) papers reported +ve findings, 9 (6%) were negative; 80 (49%) were non-conclusive; 4 (2%) contained non-extractable data.
(3) Out of 137 pacebo-controlled studies, 41 are on individualised homeopathy and 96 on non-individualised homeopathy
(4) In 32 out of 89 disease conditions, there has been replicated research (2 or more RCT). In 22 out of 32 disease conditions, the results of replicated research were statistically significant.
(5) These 22 disease conditions are:
Respiratory: Upper Respiratory Tract Infection, Influenza, rhinitis, asthma, Common Cold, Otitis Media, Sinusitis
Others: Fibromyalgia, Arsenic toxicity, Attention-deficit hyperactivity disorder, Blood coagulation, diarrhea, Depression, Female infertility, Insomnia, Irritable bowel syndrome, Low back pain, Muscle soreness, arthritis, Post-operative bruising, Post-operative pain, Vertigo
For more details go here
Ref:http://www.homeopathyjournal.net/article/S1475-4916(12)00081-1/fulltext
CONCLUSIONS
Research claims to have confirmed the efficacy of homeopathic medicine. Additional support comes from the fact that animals, plants, infants and comatose patients also benefit from homeopathic treatment and it is unlikely that they will react psychologically to a medicine they often do not know they are being given
STILL TO WORK UPON
Indian Journal of Research in Homoeopathy
Indian Journal of Research in Homoeopathy-2
If you have more information to share on research, kindly contact so that we can publish it.
For suggestions, questions and feedback, you can use comment section.
Science-based Homeopathy 
Narayana Rao
Happy to see your knol in top health knols of 2010
Regards
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