Experimental Model, Biological Model, Pharmacological Model, Pre-and post-conditioning Hormesis Model, Cytometric Protocols, Research Design
Key Persons: Jacques Benveniste, Philippe Belon, van Wijk R, Walach H
Upto the end of year 2010, there have been 22 studies on research models in homeopathy published in 12 medical journals (6 integrative, 2 homeopathy and 4 CAM journals). These 22 studies on research models are part of the total 299 human studies in evidence of homeopathy upto the end of 2010.
URL Links to 22 studies (Journal-wise) including 10 FULL TEXT PDF papers are available as compendium on this webpage as well as read at or downloaded from Google Drive
The compendium is prepared by mining 14 online electronic databases:PubMed Central (National Library of medicine, USA), MedWorm, British library Direct (type homeopathy in search box),Centre for Reviews and Dissemination(type homeopathy in search box),Scirus, Google Scholar and HomBRexThe Allied and Complementary Medicine Database,Cochrane Central Register of Controlled Trial, Excerpta Medica Database Embase,Science Citation Index,Lilacs, CAM QUESTand Clinical Outcome Research in Homeopathy (http://www.carstens-stiftung.de/core-hom/login.php)
Exclusion Criterion (What kind of studies are not included?)
1.Studies on Plants and Animals
2.Studies published in non-journal paper
3.Non-peer reviewed studies from year 1893 onwards
4.Statistically non-significant studies (Probability value<0.05, odds ratio >1, indicates statistical significance)
5.Studies in which combination of homeopathic medicine with any other medicine is prescribed
6.Studies in which medicine is perceived to be homeopathic but is not such as radionically prepared or different potencies of same medicine mixed together
A. Basophil Degranulation Model (Biological Model for high dilution research)
B. Post-Conditioning Hormesis Model
C. Quantum Macro Entanglement Model
A. BASOPHIL DEGRANULATION: INHIBITION OF BASOPHIL ACTIVATION BY POTENTISED ANTIGEN(Philippe Belon et.al., 1983)
Basophils (involved in immune response) are white blood cells extracted from blood of donors and then stimulated by potentised antibody generator (antigen) (such as histamine and apis) causing them to degranulation
1. Aspects of Research in Homeopathy
The Effects of Hahnemannian Potencies of 7c Histaminum and 7c Apis Mellifica upon Basophil Degranulation in Allergic Patients (1983), Jean Boiron, Jacky Abecassls, and Philippe Belon
Histamine 7c and Apis 7c reduces the release of certain allergy causing chemicals from basophils
2.Innovation et technologie en biologie et médecine (French) (meaning) Innovation and Technology in Biology and Medicine
Effect of Apis mellifica on the in vitro human basophil degranulation (1986) //incubation of basophils with high dilutions of Apis mellifica inhibits allergen-induced basophil
3.British Journal of Clinical Pharmacology
In vitro immunological degranulation of human basophils is modulated by Lung histamine 5c,15c,18c and Apis mellifica 9c,10c (1988) FULL TEXT // blind experiment, in-vitro
Human basophil degranulation triggered by very dilute antiserum against IgE (1988) FULL TEXT // This study is popularly known as“memory of water” study. Benveniste replicated his results 70 times. Three other labs (in Israel, Canada, Italy) replicate the results before the paper was published—an unprecedented requirement.Antiserum is blood serum containing antibodies.
5. Inflammation Research
Histamine 7c,9c,10c,13c inhibits basophil activation (2001) //Benveniste paper in Nature published in 1988 got replicated in this paper
Histamine 15-19C, 30X, 38X modulates anti-igE stimulated human basophil (CD63) activation (2004) FULL TEXT //Flow Cytometry Analysis at 4 different laboratories in Europe found that Potentised Histamine alters the activity of White Blood Cells. Peak of biological activity at 16c,,It is known as Pre-Conditioning Hormesis model (Philippe Belon et. al., 2004):The model is different to that of Benveniste; he used the same control but not the same activator.This study was replicated in two studies mentioned below.
6. Forschende Komplementärmedizin(German) meaning Research in Complimentary Medicine
Histamine 11c,12c inhibits basophil activation (2003) // in vitro
Histamine 3-20x inhibits basophil activation (2003) // in vitro
High Dilution Research models: a bibliometric study (2010) FULL TEXT//22 out of 24 experimental models were reproducible and 7 of them were independently reproducible
Conclusion: Histamine in potency below avogado’s limit such as 2c, 5c, 7c-12 c, 3x-20x as well as above avogadro’s limit such as 13c-19c modulates human basophil activation.
B.Post-Conditioning Hormesis model (Van Wijk R and Wiegant, 1997)
1. Alternative Therapies in Health and Medicine
The similia principle as a therapeutic strategy (1997) http://www.ncbi.nlm.nih.gov/pubmed/9061987 Low dose of stressor agent (represents homeopathic medicine) such as arsenic, cadmium, copper, mercury, lead, etc is applied to disturbed/stressed cell culture (represents ill patient).
C. QUANTUM MACRO ENTANGLEMENT MODEL (Walach H, 2003)
Atmanspacher, Römer & Walach (2002) proposed a model ‘Weak Quantum Theory” (generalised version of Quantum Mechanics) that predicts a generalised form of entanglement-a concept established by Schrödinger in 1935. Walach proposed ‘Entanglement model of Homeopathy‘ in 2003.
1.Forschende Komplementärmedizin und Klassische Naturheilkunde (German) meaning meaning Research in Complementary and Natural Classical Medicine
Entanglement model of Homeopathy (Walach H, 2003)
2. Forschende Komplementärmedizin
A PPR Entanglement model of homeopathy based on Quantum Field Theory (Linonel Milogram, 2006)
3. Evidence-based Complimentary & Alternative Medicine
Entanglement Theory(2007) FULL TEXT
4. Perspective in Public Health
Is Homeopathy Possible?(2006) FULL TEXT
P.S. 1. The oxygen atom has 6 electrons in its valence shell, but 8 are possible according to quantum physics.
2. A flip-flop can store 1 bit of information but 2 are possible according to quantum computers.
3. Quantum effect is pronounced on nano scale. For example nanoparticles less than 50 nanometres are small enough to confine their electrons and produce quantum effects.
D1. Research Design of DBRPCT in Homeopathy
1. The Journal of Alternative and Complementary Medicine
D2. Protocols for homeopathic practice in ICU
Last Modified: This webpage was last updated on 02 March 2015.
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