14 Research Studies in support of Nosodes

Ref: https://www.opensciencepublications.com/fulltextarticles/images/JVIT-2-106fig2.png

NOSODES Medicine prepared from causative agent (an agent which causes the pathology) such as inactivated identical disease products of human, animal or vegetable origin, or cultures of micro-organisms (bacteria, virus, fungi) is known as Nosode.

Humans: Baccilinum (tuberculous sputum), Carcinosinum (breast cancer tumour tissue), Medorrhinum, Psorinum (lysated stock obtained from serosity of furrows of the itch), Tuberculinum bovinum (pus of tuberculosis abscess in lungs), Variolinum, Pneumococcinum (diplococcus pneumoniae found in saliva)
Animals: Ambra grisea, Lyssin, Oscillococcinum (autolysate filtered from liver and heart of a duck)
Plants: Secale cornutum
Virus: Influenzinum, Syphilinum (Syphilitic Virus)
Bacteria: Streptococcinum, Leptospira (lysate of Leptospira), Staphylococcinum (endotoxins of staphylococcus)The term nosode was introduced by Dr Hering. The first nosode Psorinum was introduced in 1828.

Auto-nosodes: Nosodes prepared from the patient’s own body are known as auto-nosodes.

Isodes: Medicines prepared from identical (same) disease product are called isodes.

Treatment of disease by Isodes in potency is known as Isopathy.
Isopathy was introduced in 1833 by Johann Joseph Wilhelm Lux, Professor of Veterinary Medicine, University of Leipzig, Germany.

Auto-Isodes: Isodes prepared from patient’s own body are known as auto-isodes.

Treatment of disease by auto-isodes is known as auto-isopathy. Auto-Isopathy was introduced in 1895 by Dr Collet from Paris [3]

SAFETY PROFILE OF NOSODES

The source material of a human nosode is verified for the absence of infection. The source material is heated in saturated steam for 20 minutes at a temperature of 133-degree centigrade to make it sterile and further processed (autoclaving) to ensure microbiological safety [1].

The source material of an animal nosode has been verified by Pasteur Institute, Paris and found out to be safe for human consumption [2].

PRESCRIPTION OF NOSODES

Nosodes constitutes less than 4% of all homeopathic medicines listed in homeopathic pharmacopoeia. Use of nosodes and sarcodes in the treatment of disease conditions is known as biotherapy or immunotherapy or organopathy. Nosodes are not a routine prescription (prescribed infrequently) and are generally prescribed in the chronic conditions in 200c potency or above under specific circumstances listed below or as preventive medicine for infectious disease (homeopathic vaccines) in acute diseases to provide/increase specific immunity regarding definite etiological agents.

1. Nosode as anti-miasmatic remedy

2. Nosode as an intercurrent remedy

3. When-well indicated remedy fails to give relief

RESEARCH STUDIES

The first research study in evidence of nosodes was published in 1964. The research gained momentum when a DBRPCT on nosode Oscillococcinum for treatment of influenza was published in the British Journal of Clinical Pharmacology in 1989.

A Compendium of 14 homeopathy research papers (6 full-text PDF) in evidence of 11 nosodes [click to tweet]. The articles are classified into 3 categories: DBRPCT, basic fundamental research and Observational studies.

Inclusion Criterion: Human and in-vitro studies with statistically significant results in peer-reviewed articles in journals upto year 2012

Exclusion Criterion: plant and animal studies, radionically prepared or different potencies of same medicine mixed together

BASIC FUNDAMENTAL RESEARCH

1. Evidence-based Complementary & Alternative Medicine

Dynamized Preparations in Cell Culture (2009) FULL TEXT. Carcinosinum 200C, Conium, Lycopodium activates beneficial gene p53 which provides defense against tumour/cancer

2 Indian Journal of Research in Homoeopathy

Staphylococcinum – A multicenter clinical verification study (2012)

DOUBLE-BLIND RANDOMISED PLACEBO-CONTROLLED TRIAL (DBRPCT)

1. British Journal of Clinical Pharmacology

A controlled evaluation of a homoeopathic preparation in the treatment of influenza-like syndromes (1989) FULL TEXT

n=487, 237 treated by Oscillococcinum and 241 on placebo. If taken twice daily for 5 days significantly increased the rate of cure within two days, absence of symptoms at 48 hours, relative risk estimate significantly favour homeopathy (p=0.048), no pain and no fever (p=0.048), recovery rate (headache, stiffness, articular pain, shivering reduction) at 48 hours better in homeopathy group (p=0.032)

2. British Homoeopathic Journal

Oscillococcinum in patients with influenza-like syndromes (1998)

n=372,3 doses per day for 3 days, no spinal pain at 48 hours (p=0.03), no muscle pain at 48 hours (p=0.01), no articulate pain at 48 hours (p=0.009), Significant effect of homeopathy over placebo in influenza (p=0.0257)

3. International Journal of Oncology

Cytotoxic effects of ultra-diluted remedies on breast cancer cells (2010) FULL TEXT

in-vitro study: Carcinosin 30c, Phytolacca Decandra 200c, Conium 3c and Thuja 30c caused the death of 5000 breast cancer cell lines in the laboratory for periods of between 1 to 4 days (experiment repeated 3 times), similar to the effect of chemotherapy, but without affecting normal cells. Carcinosin and Phytolacca—achieved up to an 80% response indicating that they caused cancer cell death. By comparison, placebo solvent achieved only 30%. The effects of Carcinosin and Phytolacca were as powerful as Paclitaxel (Taxol)

4. Homeopathy

Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control (2010) FULL TEXT

2.3 million people in Cuba given two doses each (7-9 days apart) for protection against Leptospirosis (fever+jaundice+ inflammation in kidney+enlargement of spleen) with only 10 reported cases. Dramatic decrease in morbidity within two weeks and zero morbidity of hospitalised patients. Cost of homeopathic immunization =1/15th of allopathic vaccine.

OBSERVATIONAL STUDIES

1. The British Homeopathic Journal

Quadruple nosode: for the prophylaxis of respiratory infections (1964) Combination nosode: Bacillinum, Influenzinum, Pneumococcus and Streptococcus for prevention

Evaluation of 2LHERP in preventing recurrences of genital herpes (2000) combination remedy 2LHERP=homeopathic RNA+homeopathic viral DNA

Immunologic Changes in Healthy Probands and HIV Infected Patients After Oral Administration of Staphylococcus Aureus 12c (2000) Staphylococcinum 12c decreases immune complexes, increases CD4 lymphocytes in HIV patients

2. International Journal of High Dilution Research

A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic (2009) FULL-TEXT

Tuberculinum, Apis mel, Arsenicum album and sarcodes for Nephrotic Syndrome in adults

3. Homeopathy

Homeopathy in the Treatment of Tubercular Lymphadenitis (2011) Tuberculinum in the treatment of Tuberculosis of lymph nodes

4. Evidence-based Complimentary & Alternative Medicine

Psorinum Therapy in Treating Stomach, Gall Bladder, Pancreatic, and Liver Cancers (2011) FULL TEXT Psorinum 6X

5. The Journal of Alternative and Complementary Medicine

A Homeopathic Approach to Treat Patients With Advanced Gallbladder, Periampullary, and Liver Carcinomas (2012) Psorinum 6x for treatment of pancreas and other cancers

6 La Revue d’Homéopathie (French) / The Homeopathy Review