51 Research Papers on Combination Homeopathic Medicines

· homeopathy
homeopathic combination medicines
A Compendium of 51 articles (24 full-text PDF) on homeopathic combination medicines (2 or more homeopathic medicines mixed together) such as Traumeel, Sinfrontal, Zeel, Canova, etc. [click to tweet]
Inclusion Criterion: Peer-reviewed articles upto year 2010, statistically significant results, journal publication
Exclusion Criterion: plant and animal studies, radionically prepared or different potencies of same medicine mixed together

The articles are classified into 8 categories: Meta-Analysis, Systematic Reviews, double-blind randomized placebo-controlled trial (DBRPCT), DBRCT, DB, fundamental research, primary healthcare studies, Review article


Arzneimittel-Forschung (German)/Medicines Research

Treatment of Vertigo With a Homeopathic Complex Remedy Compared With Usual Treatments (2005) VertigoHeel


British Homoeopathic Journal

Homeopathic remedies for the treatment of osteoarthritis: a systematic review (2001) (by Long and E Ernst)

4 RCT with n=506, Zeel (Rhus toxiconderon+Dulcamara+Sanguinara+Arnica montana) superior to hyaluronic acid. Combination of Rhus tox, Causticum and Lac vac superior to paracetamol. AMSTAR score=6/10. Homeopathy found to be “at least as effective” as a conventional non-steroidal anti-inflammatory drug gel. “positive trend towards the effectiveness of combination homeopathic preparations”


1.Aktuelle Rheumatologie (German)/Current Rheumatology

Wirksamkeitsnachweis eines Homöopathikums bei chronischer Polyarthritis. Eine randomisierte Doppelblindstudie bei nieder-gelassenen Ärzten [A randomized double-blind trial on the efficacy of a homeopathic drug for rheumatoid arthritis] (1991)

‘Rheumaselect’ vs placebo for chronic Rheumatoid poly-arthritis. n=111. Jadad score=3

2. International Review of Allergology and Clinical Immunology

The evaluation of humoral response and the clinical evaluation of a risk-group patients’ state of health after administration of the homeopathic preparation Gripp-Heel during the influenza epidemic season 1993/94 (1999) FULL TEXT

GrippHeel=Aconitum napellus 4X+Bryonia alba 4X+Eupatorium perfoliatum 3X+Lachesis+Phosphorous

3. Explore: The Journal of Science and Healing (Elsevier)

Efficacy of a Complex Homeopathic Medication (Sinfrontal) in Patients with Acute Maxillary Sinusitis: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial (2007)

Sinfrontal (Cinnabaris 4X+Ferrum Phos 3X+etc) for acute Maxillary Sinusitis (Sinus + tooth pain). n=113

4. BMC Cancer (Wiley)

TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in cancer patients (2001) FULL TEXT. n=15, age=3-25 years, p<0.01

5. Applied Health Economics & Health Policy (Springer)

Economic Evaluation of Sinfrontal in the Treatment of Acute Maxillary Sinusitis in Adults (2009)

6. Journal of Dermatological Treatment (Taylor and Francis)

A trial of homoeopathic treatment of leg ulcers (1997) Sulphur 6 + Silicea 6 + Carbo Veg 6

7. Journal de gynécologie, obstétrique et biologie de la reproduction (French)/Journal of Gynaecology, Obstetrics and Reproductive Biology (Elsevier)

Treatment of Pain Due to Unwanted Lactation With a Homeopathic Preparation Given in the Immediate Post-Partum Period (2001) Apis 9c + Bryonia 9c

8. Der Kassenarzt (German)/The Panel Doctor

Tonsilotrena for tonsillitis (2006)

9. Zeitschrift für Allgemein Medizin (German)/Journal of General Practice

Homöopathische Therapie bei Erkrankungen der Atemwege. Auswertung einer klinischen Studie bei 258 Patienten [Homeopathic therapy in respiratory tract diseases. Evaluation of a clinical study in 258 patients] (1997) Bronchiselect for treatment of bronchitis. n=258

10. British Homoeopathic Journal

Efficacy and safety of a homeopathic gel Spiroflor SRL in the treatment of acute low back pain (2001) FULL TEXT. SRL (Symphytum + Rhustox + Ledum pal) is equally effective as Cremor Capsici Compositus FNA but has a better safety profile. n=21. high-quality study

11. The Journal of Alternative and Complementary Medicine

The Homeopathic Preparation Vertigoheel® Versus Ginkgo biloba in the Treatment of Vertigo in an Elderly Population (2005)

Homeopathy for menopausal symptoms in breast cancer survivors (2005) n=55, t= 1 year, at least 3 episodes of hot flushes per day for at least 1 month, significant improvement in quality of life, Jaded score=5, [significant improvement in homeopathy group compared to placebo, p<0.03 for combination remedy (Hyland’s Menopause)], significant improvement in hot flush severity in combination group over placebo (p=0.01), significant improvement in total number of hot flushes in combination group over placebo (p=0.006)

12. Alternative Medicine Review

Kali bromatum 1X, Natrum bromatum, Nickel sulfate 3X, Natrum mur 6X for dermatitis of scalp and dandruff (2002) FULL TEXT

13. Forschende Komplementärmedizin (German)/Complementary Medicine Research

Euphorbium Compositum for viral infection of respiratory tract (2001) FULL TEXT. in vitro

Randomized, placebo-controlled, double-blind study of the clinical efficacy of the homeopathic Euphorbium compositum-S nasal spray in cases of chronic sinusitis (1994)

n=155, Score for treatment severity was 1.37±0.30 in homeopathy patients (n = 53) and 1.44±0.34 in placebo patients (n = 51), Linde quality=5

Comparing Luffa compositum-Heel nasal spray with cromolyn sodium spray in the treatment of allergic rhinitis (1999) FULL TEXT

n=146, Luffa Compositum (Luffa + Galphimia + Histamine + Sulphur) is as efficient and well tolerable as conventional therapy Cromolyn Sodium

The Efficacy of the Complex Medication Phyto-Hypophyson L in Female, Hormone-Related Sterility (2000)

n=67. 57 % improvement in fertility rate. Homeopathic treatment seemed to influence several factors including infrequent mensuration, regulation of the menstrual cycle, regulation of hormones and enhancing ovulation

14. Arzneimittel-Forschung

“Homoeopathische kombination bel vertigo and nausea”, C.F. Claussen, J. Bergmann. G. Bertora .and E. Claussen, 34 (1984):1791-98. // vertigoheel

15. Phlebology (Macmillian)

“Complementary Treatment of Varicose Veins: A Randomised, Placebo-controlled, Double-blind Trial (1990) Edzard Ernst et al. FULL TEXT

Three doses of a popular German combination of eight homeopathic medicines were given daily for 24 days. Measures were venous filling time, leg volume, and subjective symptoms. The study found that venous filling time improved in those given the homeopathic medicines by 44%, while it deteriorated in the placebo group by 18%. Other measures also had significant differences.

16. Hals, Nasen und Ohrenärzte (German)/ Ear, Nose and Throat (Springer)

Homeopathy in acute rhino-sinusitis (2007) FULL TEXT. n=144, homeopathic treatment resulted in freedom from complaints in 90.3% of the patients & improvement in a further 8.3%, whereas in placebo group, the complaints remained unchanged or became worse in 88.9% of the patients.p>0.0001

17. International Journal of Oncology (Spandidos)

Ruta 6 induces cell deaths in brain cancer cells: A novel treatment for human brain cancer (2003) FULL TEXT. in vitro and in vivo, Ruta G 6c + Calcarea phosphoricum 3x

18. Sleep and Breathing (Thieme)

Combination remedy in the management of snoring (1999) FULL TEXT. snore stop (combination of 7 remedies), n=90, Rated improvement in homeopathy group was significantly better (35/44) compared to placebo group (21/46)


1 Archives of Otolaryngology- Head & Neck Surgery (JAMA)

VertigoHeel Vs conventional treatment of vertigo (1998) FULL TEXT // n=105, conventional treatment is Betahistine hydrochloride


1.MicroVascular Research (Elsevier)

Micro-circulatory effects of VertigoHeel on vertigo (2005) FULL TEXT


1. Clinical and Developmental Immunology (Taylor and Francis)

Traummel S activates immunocytes (2004) FULL TEXT in vitro

2. Phytotherapy Research (Wiley)

Effect of Echinacea, Aconitum, Lachesis and Apis extracts, and their combinations on phagocytosis of human granulocytes (1994) FULL TEXT

Combination of Aconitum and Lachesis 1X enhanced the phagocytic activity of granulocytes upto 390%

3.Histology and Histopathology

Investigating the Ultrastructure of Platelets of HIV Patients Treated With the Immuno-Regulator, Canova (2009)

Scanning electron microscopy to investigate the structure of platelets. Canova: Aconite 11x+Arsenicum 19x+Bryonia 18x+Lachesis 18x+Thuja 19x

4. Inflammation research

Zeel comp. N inhibits the production of Leukotriene B4; Solanum dulcamara Q inhibits the production of Prostaglandin E2 (2004) FULL TEXT // anti-inflammatory, in vitro

5. Environmental Toxicology and Pharmacology (Elsevier)

Hepeel prevented cadmium chloride-induced cell death in liver cells (2009) FULL TEXT

in vitro, China Q and Nux moschata Q provide protection against loss of glutathione and lipid peroxidation. Carduus marianus Q demonstrated anti-apoptotic effects, single & in combination


1.Explore: The Journal of Science and Healing

The effects of a complex homeopathic medicine compared with acetaminophen in the symptomatic treatment of acute febrile infections in children (2005)

n=198 in 38 Belgian clinics. febrile symptoms such as fever, cramps, disturbed sleep, difficulty eating or drinking, crying. Viburcol as effective as acetaminophen but better tolerable. Viburcol = Chamomilla+ Belladonna+Calcarea carbonica+Dulcamara+ Plantago major+Pulsatilla

A Homeopathic Ointment Preparation Compared With 1% Diclofenac Gel for Acute Symptomatic Treatment of Tendinopathy (2005) Traumeel ointment superior to diclofenac gel for tendon injuries

A Complex Homeopathic Preparation for the Symptomatic Treatment of Upper Respiratory Infections Associated With the Common Cold (2006)

Asclepias vincetoxicum and Sulphur Vs anti-histamine and anti-inflammatory drugs for the treatment of upper respiratory infections

2. Pediatrics International (Wiley)

Effects of Spascupreel versus hyoscine butylbromide for gastrointestinal cramps in children (2007)

cohort study, n=204, t=1 week, children were given either spascupreel or hyoscine butylbromide for cramps and spasms, both found equally good

3. Scientific World Journal (Hindawi)

The Homeopathic Preparation Neurexan vs. Valerian for the Treatment of Insomnia (2008)

Neurexen=Avena Sativa 2X+Passiflora Incarnata 2X+Zincum Valerianicum 4X+Coffea Cruda 12X

Effectiveness of the Homeopathic Preparation Neurexan Compared With That of Commonly Used Valerian-Based Preparations for the Treatment of Nervousness/Restlessness (2009)

The summary score for nervousness/restlessness was reduced in the Neurexan group by 11.5 ± 7.3 score units. In the valerian (other-than-placebo) group, the summary score was reduced by 9.0 ± 6.6

4. International Journal of Clinical Practice (Blackwell)

Gripp-Heel for viral infections (2004) FULL TEXT

5. Canadian Journal of Physiology and Pharmacology

Gripp-Heel for respiratory viral infections (2007) FULL TEXT. in-vitro

6. Ultrastructural Pathology

Canova differentiates monocytes in absence of cytokines (2008) FULL TEXT. in-vitro

7. Genetics and Molecular Research

Canova for cancer treatment (2003) FULL TEXT. in-vitro

8. The British Homoeopathic Journal

Quadruple nosode: for the prophylaxis of respiratory infections (1964) Quadruple nosode=Bacillinum+Influenzinum+ Pneumococcus+Streptococcus. Nosode as preventive for respiratory infections

Evaluation of 2LHERP in preventing recurrences of genital herpes (2000) // combination nosode 2LHERP=homeopathic RNA+homeopathic viral DNA

9. Homeopathy

Lymphocyte proliferation stimulated by activated human macrophages treated with Canova (2009) FULL TEXT

Macrophages treated with Canova stimulates lymphocytes proliferation in vitro

10. Complementary Therapies in Medicine (Elsevier)

The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries (2008) Traumeel for trauma and acute musculo-skeletal injuries

11. Evidence-based Complementary and Alternative Medicine

NervoHeel N for Nervous Disorders (2007) FULL TEXT //other than-placebo control: Lorazepam

12. The Journal of Alternative and Complementary Medicine

Investigation of Cytokine Expression in Human Leukocyte Cultures With Two Immune-Modulatory Homeopathic Preparations (2007) Phase 6 and Flu Terminator elicits human immune response in-vitro

13.Forschende Komplementärmedizin und Klassische Naturheilkunde (German /Research in Complementary and Classical Natural Medicine

Treatment of Inflammatory Diseases of the Upper Respiratory Tract — Comparison of a Homeopathic Complex Remedy With Xylometazoline (2005) Treatment of rhinitis & sinusitis with Euphorbium compositum nasal drops. n=739

14. Arzneimittel-Forschung (Thieme)

Antioxidative, Antiproliferative and Biochemical Effects in HepG2 Cells of a Homeopathic Remedy and Its Constituent Plant Tinctures Tested Separately or in Combination (2003)

Antioxidative, antiproliferative and biochemical effects of Hepeel in HepG2 cells. Heepel=Carduus marianus+ Cinchona+ Lycopodium+ Nux moschata+ Colocynthis D6+ Veratrum album D6+ Chelidonium,+Phosphorus D6

15. STP Pharma Sciences

Anti-inflammatory action of combination of Urtica Urens 4c and Apis 4c AND Belladonna 4c and Pulsatilla 4c (1999)

16. Journal of Musculoskeletal Research

Traumeel vs NSAID for inflammation of the epicondyle (2004) FULL TEXT. Traumeel superior to NSAID on variable pain at rest (p<0.01), joint mobility (p<0.01)


1. Homeopathy

Canova as Immunomodulator (2009) FULL TEXT. in vitro


DISTRIBUTION OF STUDIES on combination remedies (till 2010)
Type of Research No. of studies No. of Journals Type of Journal
Combination Remedies
34 29 Integrative
6 1 Homeopathy
11 6 CAM
51 36

DETAILED ANALYSIS on combination remedies(Published till 2010)
Type of Research No. of studies No. of Journals Type of Journal
Meta Analysis 1 1 Integrative
Systematic Review 1 1 Homeopathy
15 15 Integrative
1 1 Homeopathy
6 3 CAM
22 19
Fundamental Studies 4 4 Integrative
1 1 CAM
5 5
Double-Blind Studies 1 1 Integrative
Observational Studies
12 10 Integrative
2 1 Homeopathy
4 4 CAM
18 15
Review Article 1 1 Homeopathy

24 Full-text papers in PDF are available for downloaded at Google Drive

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Last Modified: This webpage was last updated on 25 May 2020

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