The articles are classified into 8 categories: Meta-Analysis, Systematic Reviews, double-blind randomized placebo-controlled trial (DBRPCT), DBRCT, DB, fundamental research, primary healthcare studies, Review article
META-ANALYSIS
Arzneimittel-Forschung (German)/Medicines Research
Treatment of Vertigo With a Homeopathic Complex Remedy Compared With Usual Treatments (2005) VertigoHeel
SYSTEMATIC REVIEW
British Homoeopathic Journal
Homeopathic remedies for the treatment of osteoarthritis: a systematic review (2001) (by Long and E Ernst)
4 RCT with n=506, Zeel (Rhus toxiconderon+Dulcamara+Sanguinara+Arnica montana) superior to hyaluronic acid. Combination of Rhus tox, Causticum and Lac vac superior to paracetamol. AMSTAR score=6/10. Homeopathy found to be “at least as effective” as a conventional non-steroidal anti-inflammatory drug gel. “positive trend towards the effectiveness of combination homeopathic preparations”
DOUBLE-BLIND RANDOMISED PLACEBO-CONTROLLED TRIAL
1.Aktuelle Rheumatologie (German)/Current Rheumatology
Wirksamkeitsnachweis eines Homöopathikums bei chronischer Polyarthritis. Eine randomisierte Doppelblindstudie bei nieder-gelassenen Ärzten [A randomized double-blind trial on the efficacy of a homeopathic drug for rheumatoid arthritis] (1991)
‘Rheumaselect’ vs placebo for chronic Rheumatoid poly-arthritis. n=111. Jadad score=3
2. International Review of Allergology and Clinical Immunology
GrippHeel=Aconitum napellus 4X+Bryonia alba 4X+Eupatorium perfoliatum 3X+Lachesis+Phosphorous
3. Explore: The Journal of Science and Healing (Elsevier)
Sinfrontal (Cinnabaris 4X+Ferrum Phos 3X+etc) for acute Maxillary Sinusitis (Sinus + tooth pain). n=113
4. BMC Cancer (Wiley)
TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in cancer patients (2001) FULL TEXT. n=15, age=3-25 years, p<0.01
5. Applied Health Economics & Health Policy (Springer)
Economic Evaluation of Sinfrontal in the Treatment of Acute Maxillary Sinusitis in Adults (2009)
6. Journal of Dermatological Treatment (Taylor and Francis)
A trial of homoeopathic treatment of leg ulcers (1997) Sulphur 6 + Silicea 6 + Carbo Veg 6
7. Journal de gynécologie, obstétrique et biologie de la reproduction (French)/Journal of Gynaecology, Obstetrics and Reproductive Biology (Elsevier)
Treatment of Pain Due to Unwanted Lactation With a Homeopathic Preparation Given in the Immediate Post-Partum Period (2001) Apis 9c + Bryonia 9c
8. Der Kassenarzt (German)/The Panel Doctor
Tonsilotrena for tonsillitis (2006)
9. Zeitschrift für Allgemein Medizin (German)/Journal of General Practice
Homöopathische Therapie bei Erkrankungen der Atemwege. Auswertung einer klinischen Studie bei 258 Patienten [Homeopathic therapy in respiratory tract diseases. Evaluation of a clinical study in 258 patients] (1997) Bronchiselect for treatment of bronchitis. n=258
10. British Homoeopathic Journal
Efficacy and safety of a homeopathic gel Spiroflor SRL in the treatment of acute low back pain (2001) FULL TEXT. SRL (Symphytum + Rhustox + Ledum pal) is equally effective as Cremor Capsici Compositus FNA but has a better safety profile. n=21. high-quality study
11. The Journal of Alternative and Complementary Medicine
Homeopathy for menopausal symptoms in breast cancer survivors (2005) n=55, t= 1 year, at least 3 episodes of hot flushes per day for at least 1 month, significant improvement in quality of life, Jaded score=5, [significant improvement in homeopathy group compared to placebo, p<0.03 for combination remedy (Hyland’s Menopause)], significant improvement in hot flush severity in combination group over placebo (p=0.01), significant improvement in total number of hot flushes in combination group over placebo (p=0.006)
12. Alternative Medicine Review
Kali bromatum 1X, Natrum bromatum, Nickel sulfate 3X, Natrum mur 6X for dermatitis of scalp and dandruff (2002) FULL TEXT
13. Forschende Komplementärmedizin (German)/Complementary Medicine Research
Euphorbium Compositum for viral infection of respiratory tract (2001) FULL TEXT. in vitro
n=155, Score for treatment severity was 1.37±0.30 in homeopathy patients (n = 53) and 1.44±0.34 in placebo patients (n = 51), Linde quality=5
Comparing Luffa compositum-Heel nasal spray with cromolyn sodium spray in the treatment of allergic rhinitis (1999) FULL TEXT
n=146, Luffa Compositum (Luffa + Galphimia + Histamine + Sulphur) is as efficient and well tolerable as conventional therapy Cromolyn Sodium
The Efficacy of the Complex Medication Phyto-Hypophyson L in Female, Hormone-Related Sterility (2000)
n=67. 57 % improvement in fertility rate. Homeopathic treatment seemed to influence several factors including infrequent mensuration, regulation of the menstrual cycle, regulation of hormones and enhancing ovulation
14. Arzneimittel-Forschung
“Homoeopathische kombination bel vertigo and nausea”, C.F. Claussen, J. Bergmann. G. Bertora .and E. Claussen, 34 (1984):1791-98. // vertigoheel
15. Phlebology (Macmillian)
“Complementary Treatment of Varicose Veins: A Randomised, Placebo-controlled, Double-blind Trial (1990) Edzard Ernst et al. FULL TEXT
Three doses of a popular German combination of eight homeopathic medicines were given daily for 24 days. Measures were venous filling time, leg volume, and subjective symptoms. The study found that venous filling time improved in those given the homeopathic medicines by 44%, while it deteriorated in the placebo group by 18%. Other measures also had significant differences.
16. Hals, Nasen und Ohrenärzte (German)/ Ear, Nose and Throat (Springer)
Homeopathy in acute rhino-sinusitis (2007) FULL TEXT. n=144, homeopathic treatment resulted in freedom from complaints in 90.3% of the patients & improvement in a further 8.3%, whereas in placebo group, the complaints remained unchanged or became worse in 88.9% of the patients.p>0.0001
17. International Journal of Oncology (Spandidos)
Ruta 6 induces cell deaths in brain cancer cells: A novel treatment for human brain cancer (2003) FULL TEXT. in vitro and in vivo, Ruta G 6c + Calcarea phosphoricum 3x
18. Sleep and Breathing (Thieme)
Combination remedy in the management of snoring (1999) FULL TEXT. snore stop (combination of 7 remedies), n=90, Rated improvement in homeopathy group was significantly better (35/44) compared to placebo group (21/46)
DBRCT
1 Archives of Otolaryngology- Head & Neck Surgery (JAMA)
VertigoHeel Vs conventional treatment of vertigo (1998) FULL TEXT // n=105, conventional treatment is Betahistine hydrochloride
DOUBLE BLIND STUDIES
1.MicroVascular Research (Elsevier)
Micro-circulatory effects of VertigoHeel on vertigo (2005) FULL TEXT
FUNDAMENTAL RESEARCH
1. Clinical and Developmental Immunology (Taylor and Francis)
Traummel S activates immunocytes (2004) FULL TEXT in vitro
2. Phytotherapy Research (Wiley)
Effect of Echinacea, Aconitum, Lachesis and Apis extracts, and their combinations on phagocytosis of human granulocytes (1994) FULL TEXT
Combination of Aconitum and Lachesis 1X enhanced the phagocytic activity of granulocytes upto 390%
3.Histology and Histopathology
Scanning electron microscopy to investigate the structure of platelets. Canova: Aconite 11x+Arsenicum 19x+Bryonia 18x+Lachesis 18x+Thuja 19x
4. Inflammation research
Zeel comp. N inhibits the production of Leukotriene B4; Solanum dulcamara Q inhibits the production of Prostaglandin E2 (2004) FULL TEXT // anti-inflammatory, in vitro
5. Environmental Toxicology and Pharmacology (Elsevier)
Hepeel prevented cadmium chloride-induced cell death in liver cells (2009) FULL TEXT
in vitro, China Q and Nux moschata Q provide protection against loss of glutathione and lipid peroxidation. Carduus marianus Q demonstrated anti-apoptotic effects, single & in combination
PRIMARY HEALTH CARE (COHORT/OBSERVATIONAL/PILOT) STUDIES
1.Explore: The Journal of Science and Healing
n=198 in 38 Belgian clinics. febrile symptoms such as fever, cramps, disturbed sleep, difficulty eating or drinking, crying. Viburcol as effective as acetaminophen but better tolerable. Viburcol = Chamomilla+ Belladonna+Calcarea carbonica+Dulcamara+ Plantago major+Pulsatilla
A Homeopathic Ointment Preparation Compared With 1% Diclofenac Gel for Acute Symptomatic Treatment of Tendinopathy (2005) Traumeel ointment superior to diclofenac gel for tendon injuries
Asclepias vincetoxicum and Sulphur Vs anti-histamine and anti-inflammatory drugs for the treatment of upper respiratory infections
2. Pediatrics International (Wiley)
Effects of Spascupreel versus hyoscine butylbromide for gastrointestinal cramps in children (2007)
cohort study, n=204, t=1 week, children were given either spascupreel or hyoscine butylbromide for cramps and spasms, both found equally good
3. Scientific World Journal (Hindawi)
The Homeopathic Preparation Neurexan vs. Valerian for the Treatment of Insomnia (2008)
Neurexen=Avena Sativa 2X+Passiflora Incarnata 2X+Zincum Valerianicum 4X+Coffea Cruda 12X
The summary score for nervousness/restlessness was reduced in the Neurexan group by 11.5 ± 7.3 score units. In the valerian (other-than-placebo) group, the summary score was reduced by 9.0 ± 6.6
4. International Journal of Clinical Practice (Blackwell)
Gripp-Heel for viral infections (2004) FULL TEXT
5. Canadian Journal of Physiology and Pharmacology
Gripp-Heel for respiratory viral infections (2007) FULL TEXT. in-vitro
6. Ultrastructural Pathology
Canova differentiates monocytes in absence of cytokines (2008) FULL TEXT. in-vitro
7. Genetics and Molecular Research
Canova for cancer treatment (2003) FULL TEXT. in-vitro
8. The British Homoeopathic Journal
Quadruple nosode: for the prophylaxis of respiratory infections (1964) Quadruple nosode=Bacillinum+Influenzinum+ Pneumococcus+Streptococcus. Nosode as preventive for respiratory infections
Evaluation of 2LHERP in preventing recurrences of genital herpes (2000) // combination nosode 2LHERP=homeopathic RNA+homeopathic viral DNA
9. Homeopathy
Lymphocyte proliferation stimulated by activated human macrophages treated with Canova (2009) FULL TEXT
Macrophages treated with Canova stimulates lymphocytes proliferation in vitro
10. Complementary Therapies in Medicine (Elsevier)
The role of a homoeopathic preparation compared with conventional therapy in the treatment of injuries (2008) Traumeel for trauma and acute musculo-skeletal injuries
11. Evidence-based Complementary and Alternative Medicine
NervoHeel N for Nervous Disorders (2007) FULL TEXT //other than-placebo control: Lorazepam
12. The Journal of Alternative and Complementary Medicine
Investigation of Cytokine Expression in Human Leukocyte Cultures With Two Immune-Modulatory Homeopathic Preparations (2007) Phase 6 and Flu Terminator elicits human immune response in-vitro
13.Forschende Komplementärmedizin und Klassische Naturheilkunde (German /Research in Complementary and Classical Natural Medicine
Treatment of Inflammatory Diseases of the Upper Respiratory Tract — Comparison of a Homeopathic Complex Remedy With Xylometazoline (2005) Treatment of rhinitis & sinusitis with Euphorbium compositum nasal drops. n=739
14. Arzneimittel-Forschung (Thieme)
Antioxidative, antiproliferative and biochemical effects of Hepeel in HepG2 cells. Heepel=Carduus marianus+ Cinchona+ Lycopodium+ Nux moschata+ Colocynthis D6+ Veratrum album D6+ Chelidonium,+Phosphorus D6
15. STP Pharma Sciences
16. Journal of Musculoskeletal Research
Traumeel vs NSAID for inflammation of the epicondyle (2004) FULL TEXT. Traumeel superior to NSAID on variable pain at rest (p<0.01), joint mobility (p<0.01)
REVIEW ARTICLE
1. Homeopathy
Canova as Immunomodulator (2009) FULL TEXT. in vitro
CONCLUSION
| Type of Research | No. of studies | No. of Journals | Type of Journal |
| Combination Remedies (1964-2009) |
34 | 29 | Integrative |
| 6 | 1 | Homeopathy | |
| 11 | 6 | CAM | |
| 51 | 36 |
| Type of Research | No. of studies | No. of Journals | Type of Journal |
| Meta Analysis | 1 | 1 | Integrative |
| Systematic Review | 1 | 1 | Homeopathy |
| DBRCT (1984-2009) |
15 | 15 | Integrative |
| 1 | 1 | Homeopathy | |
| 6 | 3 | CAM | |
| 22 | 19 | ||
| Fundamental Studies | 4 | 4 | Integrative |
| 1 | 1 | CAM | |
| 5 | 5 | ||
| Double-Blind Studies | 1 | 1 | Integrative |
| Observational Studies (1964-2009) |
12 | 10 | Integrative |
| 2 | 1 | Homeopathy | |
| 4 | 4 | CAM | |
| 18 | 15 | ||
| Review Article | 1 | 1 | Homeopathy |
24 Full-text papers in PDF are available for downloaded at Google Drive
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