Experimental Model, Biological Model, Pharmacological Model, Pre-Conditioning Hormesis Model, Cytometric Protocols, Research Design
Key Persons: Jacques Benveniste, Philippe Belon, Walach H
Upto the end of year 2010, there have been 22 studies on research models in homeopathy published in 12 peer-reviewed medical journals. These 22 studies on research models are part of the total 304 human studies in evidence of homeopathy upto the end of 2010.
1. 22 studies does not include studies on plants and animals
2. 22 studies does not include ‘positive but statistically non-significant’ studies.
3. 12 journals comprises of 6 integrative, 2 homeopathy and 4 CAM journals
4. URL Links to 22 studies (Journal-wise) including 10 FULL TEXT PDF papers are available as compendium on this webpage as well as read at or downloaded from Google Drive
The compendium is prepared by mining 7 online databases:PubMed Central (National Library of medicine, USA), MedWorm, British library Direct (type homeopathy in search box),Centre for Reviews and Dissemination(type homeopathy in search box),Scirus, Google Scholar and HomBRex
A. Basophil Degranulation Model (Biological Model for high dilution research)
B. Quantum Macro Entanglement Model
A. BASOPHIL DEGRANULATION: INHIBITION OF BASOPHIL ACTIVATION BY POTENTISED HISTAMINE(Philippe Belon et.al., 1983)
Basophils (involved in immune response) are white blood cells extracted from blood of donors and then stimulated by potentised antigen (histamine, apis) causing them to degranulation
1. Aspects of Research in Homeopathy
The Effects of Hahnemannian Potencies of 7c Histaminum and 7c Apis Mellifica upon Basophil Degranulation in Allergic Patients (1983),Jean Boiron, Jacky Abecassls, and Philippe Belon
Histamine 7c and Apis 7c reduces the release of certain allergy causing chemicals from basophils
2.Innovation et technologie en biologie et médecine (French) (meaning) Innovation and Technology in Biology and Medicine
Effect of Apis mellifica on the in vitro human basophil degranulation (1986) //incubation of basophils with high dilutions of Apis mellifica inhibits allergen-induced basophil
3.British Journal of Clinical Pharmacology
In vitro immunological degranulation of human basophils is modulated by Lung histamine 5c,15c,18c and Apis mellifica 9c,10c (1988) FULL TEXT // blind experiment, in-vitro
Human basophil degranulation triggered by very dilute antiserum against IgE (1988) FULL TEXT // This study is popularly known as“memory of water” study. Benveniste replicated his results 70 times. Three other labs (in Israel, Canada, Italy) replicate the results before the paper was published—an unprecedented requirement.
5. Inflammation Research
Histamine 7c,9c,10c,13c inhibits basophil activation (2001) //Beneviste paper in Nature published in 1988 got replicated in this paper
Histamine 15-19C modulates anti-igE stimulated human basophil (CD63) activation (2004) FULL TEXT //Flow Cytometry Analysis at 4 different laboratories in Europe found that Potentised Histamine alters the activity of White Blood Cells. Peak of biological activity at 16c,,It is known asPre-Conditioning Hormesis model(Philippe Belon et. al., 2004):The model is different to that of Benveniste; he used the same control but not the same activator.This study was replicated in two studies mentioned below.
6. Forschende Komplementärmedizin(German) meaning Research in Complimentary Medicine
Histamine 11c,12c inhibits basophil activation (2003) // in vitro
Histamine 3-20x inhibits basophil activation (2003) // in vitro
High Dilution Research models: a bibliometric study (2010) FULL TEXT//22 out of 24 experimental models were reproducible and 7 of them were independently reproducible
8. European Journal of Integrative Medicine
Conclusion: Histamine in potency below avogado’s limit such as 2c, 5c, 7c-12 c, 3x-20x as well as above avogadro’s limit such as 13c-19c modulates human basophil activation.
B. QUANTUM MACRO ENTANGLEMENT MODEL (Walach H, 2003)
Atmanspacher, Römer & Walach (2002) proposed a model ‘Weak Quantum Theory” (generalised version of Quantum Mechanics) that predicts a generalised form of entanglement-a concept established by Schrödinger in 1935. Walach proposed ‘Entanglement model of Homeopathy‘ in 2003.
1.Forschende Komplementärmedizin und Klassische Naturheilkunde (German) meaning meaning Research in Complementary and Natural Classical Medicine
Entanglement model of Homeopathy (Walach H, 2003)
2. Forschende Komplementärmedizin
A PPR Entanglement model of homeopathy based on Quantum Field Theory (Linonel Milogram, 2006)
3. Evidence-based Complimentary & Alternative Medicine
Entanglement Theory(2007) FULL TEXT
4. Perspective in Public Health
Is Homeopathy Possible?(2006) FULL TEXT
P.S. 1. The oxygen atom has 6 electrons in its valence shell, but 8 are possible according to quantum physics.
2. A flip-flop can store 1 bit of information but 2 are possible according to quantum computers.
3. Quantum effect is pronounced on nano scale. For example nanoparticles less than 50 nanometres are small enough to confine their electrons and produce quantum effects.
C1. Research Design of DBRPCT in Homeopathy
1. The Journal of Alternative and Complementary Medicine
C2. Protocols for homeopathic practice in ICU
Type of Research
No. of studies
No. of Journals
Type of Journal